Use of Germline BRCA Testing in Patients With Ovarian Cancer and Commercial Insurance
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2021.42703
Abstract: This cross-sectional study evaluates changes in the rate of germline BRCA testing among patients with ovarian cancer between 2008 and 2018 and analyzes factors associated with testing rates. read more here.
Keywords: patients ovarian; brca testing; germline brca; ovarian cancer ... See more keywords
Patient‐centered outcomes in the POLO study of active maintenance olaparib for germline BRCA‐mutated metastatic pancreatic cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer"
DOI: 10.1002/cncr.34610
Abstract: The phase 3 POLO study demonstrated a significant progression‐free survival (PFS) benefit and preserved health‐related quality of life (HRQOL) for active maintenance treatment with olaparib vs placebo in patients with metastatic pancreatic cancer and a… read more here.
Keywords: metastatic pancreatic; germline brca; pancreatic cancer; active maintenance ... See more keywords
Germline BRCA mutation in male carriers—ripe for precision oncology?
Sign Up to like & getrecommendations! Published in 2017 at "Prostate Cancer and Prostatic Diseases"
DOI: 10.1038/s41391-017-0018-5
Abstract: BackgroundProstate cancer (PC) is one of the known heritable cancers with individual variations attributed to genetic factors. BRCA1 and BRCA2 are tumour suppressor genes with crucial roles in repairing DNA and thereby maintaining genomic integrity.… read more here.
Keywords: risk; germline brca; brca mutations; brca mutation ... See more keywords
Abstract P3-08-06: Screening, management, cancer diagnoses, and outcomes of women with germline BRCA mutations in Israel: The Noga Clinic experience
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs16-p3-08-06
Abstract: Background: Women with germline BRCA (gBRCA) mutations in the United States are typically diagnosed at the time of cancer diagnosis and most often undergo bilateral mastectomy. Israel9s population of 8 million includes over 3 million… read more here.
Keywords: women germline; germline brca; breast; age ... See more keywords
Clinical significance of pathogenic variants in germline BRCA wild type patients at risk for hereditary breast cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e13127
Abstract: e13127 Background: Approximately, 10% of breast cancer (BC) are related to inherited germline mutations. BRCA1/2, the most recognized and tested genes, are responsible for 50% of hereditary BC. Genetic testing for hereditary BC has changed… read more here.
Keywords: patients risk; germline brca; breast cancer; clinical significance ... See more keywords
Similar response rates and survival with PARPi treatments for patients harboring somatic versus germline BRCA mutations: A meta-analysis and systematic review.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.e16802
Abstract: e16802Background: PARP inhibitor (PARPi) has recently been approved for various cancers. However, trials have mostly recruited pts with germline BRCA (gBRCA) mutations, and it is unclear whether PA... read more here.
Keywords: germline brca; rates survival; similar response; response rates ... See more keywords
Correlation of HRD status with clinical and survival outcomes in patients with advanced-stage ovarian cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.15_suppl.5568
Abstract: 5568 Background: Nearly 50% of patients with high grade ovarian cancer (HGOC) harbor a germline or somatic mutation in BRCA1/BRCA2 or have tumors characterized by homologous recombination deficiency (HRD). HRD is associated with response to… read more here.
Keywords: brca hrd; hrd status; hrd; germline brca ... See more keywords
A new targeted treatment for patients with a germline BRCA mutation: olaparib in pancreatic cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Future oncology"
DOI: 10.2217/fon-2020-0334
Abstract: Pancreatic cancer has a poor prognosis. Focused efforts in the development of novel treatments of this disease have led to the approval of new combinations. Improvements in knowledge of the biology of these tumors have… read more here.
Keywords: germline brca; olaparib pancreatic; brca mutation; pancreatic cancer ... See more keywords
Overview on population screening for carriers with germline BRCA mutation in China
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1002360
Abstract: Carriers with BRCA1/2 germline pathogenic variants are associated with a high risk of breast and ovarian cancers (also pancreatic and prostate cancers). While the spectrum on germline BRCA mutations among the Chinese population shows ethnic… read more here.
Keywords: germline brca; brca mutation; carriers germline; mutation ... See more keywords
Local Laboratory Testing of Germline BRCA Mutations vs. Myriad: A Single-Institution Experience in Korea
Sign Up to like & getrecommendations! Published in 2021 at "Diagnostics"
DOI: 10.3390/diagnostics11020370
Abstract: Genetic diagnosis for human epidermal growth factor receptor 2-negative metastatic breast cancer patients with the germline BRCA (gBRCA) mutation has been emphasized since the development of polyadenosine diphosphate-ribose polymerase inhibitors. Myriad Genetics, Inc.’s (Salt Lake… read more here.
Keywords: local laboratory; germline brca; laboratory testing; testing germline ... See more keywords
Impact of Breast Cancer and Germline BRCA Pathogenic Variants on Fertility Preservation in Young Women
Sign Up to like & getrecommendations! Published in 2023 at "Life"
DOI: 10.3390/life13040930
Abstract: Background: Several studies have suggested that breast cancer (BC) and germline BRCA pathogenic variants (gBRCA PVs) could have a deleterious impact on ovarian reserve. Nevertheless, data are limited and mixed. Our objective was to evaluate… read more here.
Keywords: pathogenic variants; germline brca; cancer germline; breast cancer ... See more keywords