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Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34304
Abstract: The outcomes and best treatment strategies for germline BRCA1/2 mutation (gBRCAm) carriers with metastatic breast cancer (MBC) remain uncertain. We compared the overall survival and the first line progression free survival (PFS1) of patients with…
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Keywords:
germline brca1;
survival;
status;
metastatic breast ... See more keywords
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Published in 2021 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-020-06070-x
Abstract: Germline BRCA1/2 mutation carriers (gBMC) face increased cancer risks that are modulated via non-genetic lifestyle factors whose underlying molecular mechanisms are unknown. The peptides Neurotensin (NT) and Enkephalin (ENK)—involved in tumorigenesis and obesity-related diseases—are of…
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Keywords:
intervention;
lifestyle intervention;
mutation carriers;
molecular mechanisms ... See more keywords
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Published in 2021 at "European journal of cancer"
DOI: 10.1016/j.ejca.2020.12.007
Abstract: BACKGROUND BRCA1 and BRCA2 play a central role in DNA repair. Therefore, patients harbouring germline (g) BRCA1/2 mutations (m) treated with chemotherapy might be at higher risk of haematological toxicities. METHODS Patients from German Breast…
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Keywords:
chemotherapy;
brca1;
haematological toxicities;
cancer ... See more keywords
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Published in 2021 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2021.10.072
Abstract: BACKGROUND Histology restricted genetic predisposition testing of ovarian carcinoma patients is a topic of debate as the prevalence of BRCA1/2 pathogenic variants (PVs) in various histological subtypes is ambiguous. Our primary aim was to investigate…
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Keywords:
histological subtypes;
brca1;
ovarian carcinoma;
germline brca1 ... See more keywords
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Published in 2017 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-16-2796
Abstract: Purpose: Rucaparib is a potent, oral, small-molecule PARP inhibitor. This phase I–II study was the first to evaluate single-agent oral rucaparib at multiple doses. Experimental Design: Part 1 (phase I) sought to determine the MTD,…
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Keywords:
brca1 mutated;
rucaparib;
parp inhibitor;
phase study ... See more keywords
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Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e13628
Abstract: e13628Background: The Philippines has the highest reported incidence of breast cancer (BC) in Southeast Asia, with a rate of 47.7 per 100,000 per year. 5 to 10% of BC results from a hereditary pred...
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Keywords:
incidence;
brca2 mutations;
incidence germline;
brca1 brca2 ... See more keywords
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Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.810099
Abstract: Background Whether neoadjuvant chemotherapy (NAC) followed by interval debulking surgery (IDS) against primary debulking surgery (PDS) has a differential effect on prognosis due to Breast Cancer Susceptibility Genes (BRCA)1/2 mutations has not been confirmed by…
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Keywords:
cancer;
study;
germline brca1;
neoadjuvant chemotherapy ... See more keywords
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Published in 2023 at "Cancers"
DOI: 10.3390/cancers15010306
Abstract: Simple Summary Germline BRCA2 pathogenic variant carriers are associated with prostate cancer risk. Ashkenazi Jewish people are at higher risk of breast cancer due to the high prevalence of specific founder germline BRCA1/2 variants. The…
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Keywords:
prostate cancer;
germline brca1;
non ashkenazi;
brca1 variants ... See more keywords
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Published in 2023 at "Cancers"
DOI: 10.3390/cancers15030730
Abstract: Simple Summary Approximately 15% of patients diagnosed with high-grade non-mucinous epithelial ovarian cancer (EOC) have a germline BRCA1/2 mutation, although all patients are often able to access germline testing. Importantly, the risk of familial ovarian…
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Keywords:
brca1;
high grade;
germline brca1;
germline ... See more keywords
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Published in 2022 at "Genes"
DOI: 10.3390/genes13061085
Abstract: The prevalence of germline BRCA1 or BRCA2 pathogenic variants (gBRCA1/2-PV) in patients with primary epithelial ovarian cancer (OC) in a rural area of Japan and their association with clinical characteristics, including treatment response and survival…
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Keywords:
germline brca1;
area;
ovarian cancer;
clinical characteristics ... See more keywords