Radiation-Induced Colitis in a Pancreatic Cancer Patient With a Germline BRCA2 Mutation: A Case Report
Sign Up to like & getrecommendations! Published in 2019 at "Advances in Radiation Oncology"
DOI: 10.1016/j.adro.2018.08.025
Abstract: Abstract Borderline resectable pancreatic cancer (BRPC) is increasingly treated with neoadjuvant chemotherapy and chemoradiation (CRT). Gastrointestinal (GI) toxicities are a main concern when designing radiation treatment plans for BRPC. BRCA1 and 2 deleterious mutations result… read more here.
Keywords: germline brca2; case report; pancreatic cancer; radiation ... See more keywords
Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms13671
Abstract: Germline mutations in the BRCA2 tumour suppressor are associated with both an increased lifetime risk of developing prostate cancer (PCa) and increased risk of aggressive disease. To understand this aggression, here we profile the genomes… read more here.
Keywords: brca2 mutations; germline brca2; mutant pca; brca2 ... See more keywords
Dramatic response of FOLFIRINOX regimen in a collision pancreatic adenocarcinoma patient with a germline BRCA2 mutation: a case report.
Sign Up to like & getrecommendations! Published in 2019 at "Japanese journal of clinical oncology"
DOI: 10.1093/jjco/hyz141
Abstract: Germline BRCA1 and BRCA2 mutations are the most common gene mutations in familial pancreatic adenocarcinoma. Several reports have demonstrated the utility of platinum-based chemotherapy for treating cancer patients who harbour a BRCA mutation. Here we… read more here.
Keywords: germline brca2; adenocarcinoma; pancreatic adenocarcinoma; brca2 mutation ... See more keywords
Response of germline BRCA2-mutated advanced pancreatic acinar cell carcinoma to olaparib
Sign Up to like & getrecommendations! Published in 2018 at "Medicine"
DOI: 10.1097/md.0000000000013113
Abstract: Rationale: Pancreatic acinar cell carcinoma (PACC) is a relatively rare malignancy of the exocrine pancreas. BRCA2, a cancer susceptibility gene, has been widely studied in breast and ovarian carcinomas as mutation carriers for this gene… read more here.
Keywords: pancreatic acinar; cell carcinoma; germline brca2; acinar cell ... See more keywords
Exceptional Response of Pancreatic Acinar Cell Carcinoma and Bile Duct Cancer to Platinum-Based Chemotherapy in a Family With a Germline BRCA2 Variant.
Sign Up to like & getrecommendations! Published in 2022 at "Pancreas"
DOI: 10.1097/mpa.0000000000002150
Abstract: ABSTRACT Pancreatic cancer and its rare subtype, acinar cell carcinoma (PACC), frequently harbor germline and/or somatic variants in homologous recombinant genes, including BRCA2. Individuals possessing germline pathogenic BRCA2 variants are known to have a higher… read more here.
Keywords: germline; brca2; brca2 variant; acinar cell ... See more keywords
Germline BRCA2 variants in advanced pancreatic acinar cell carcinoma: A case report and review of literature
Sign Up to like & getrecommendations! Published in 2022 at "World Journal of Gastroenterology"
DOI: 10.3748/wjg.v28.i45.6421
Abstract: BACKGROUND Pancreatic acinar cell carcinoma (PACC) is a rare tumor. Up to 45% of PACCs have alterations in the DNA damage repair pathway and 23% harbor rearrangements in the BRAF or RAF1 genes. We present… read more here.
Keywords: germline; pancreatic acinar; case; acinar cell ... See more keywords