Naive B Cells with High‐Avidity Germline‐Encoded Antigen Receptors Produce Persistent IgM+ and Transient IgG+ Memory B Cells
Sign Up to like & getrecommendations! Published in 2018 at "Immunity"
DOI: 10.1016/j.immuni.2018.04.019
Abstract: &NA; Although immune memory often lasts for life, this is not the case for certain vaccines in some individuals. We sought a mechanism for this phenomenon by studying B cell responses to phycoerythrin (PE). PE… read more here.
Keywords: germline encoded; memory cells; antigen; naive cells ... See more keywords
Functional convergence of a germline-encoded neutralizing antibody response in rhesus macaques immunized with HCV envelope glycoproteins.
Sign Up to like & getrecommendations! Published in 2021 at "Immunity"
DOI: 10.1016/j.immuni.2021.02.013
Abstract: Human IGHV1-69-encoded broadly neutralizing antibodies (bnAbs) that target the hepatitis C virus (HCV) envelope glycoprotein (Env) E2 are important for protection against HCV infection. An IGHV1-69 ortholog gene, VH1.36, is preferentially used for bnAbs isolated… read more here.
Keywords: germline encoded; hcv; convergence germline; rhesus macaques ... See more keywords
Germline-encoded amino acid–binding motifs drive immunodominant public antibody responses
Sign Up to like & getrecommendations! Published in 2023 at "Science"
DOI: 10.1126/science.adc9498
Abstract: Despite the vast diversity of the antibody repertoire, infected individuals often mount antibody responses to precisely the same epitopes within antigens. The immunological mechanisms underpinning this phenomenon remain unknown. By mapping 376 immunodominant “public epitopes”… read more here.
Keywords: public epitopes; immunodominant public; grab motifs; germline encoded ... See more keywords
Pan-neutralizing, germline-encoded antibodies against SARS-CoV-2: Addressing the long-term problem of escape variants
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1032574
Abstract: Despite the initially reported high efficacy of vaccines directed against ancestral SARS-CoV-2, repeated infections in both unvaccinated and vaccinated populations remain a major global health challenge. Because of mutation-mediated immune escape by variants-of-concern (VOC), approved… read more here.
Keywords: long term; escape variants; pan neutralizing; germline encoded ... See more keywords