Prevalence of Germline Findings Among Tumors From Cancer Types Lacking Hereditary Testing Guidelines
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.13070
Abstract: Key Points Question What is the prevalence of germline findings in cancers lacking hereditary testing guidelines? Findings In this cross-sectional study including records from 34 642 patients, approximately 7% of patients with cancer harbored pathogenic or… read more here.
Keywords: germline findings; hereditary testing; lacking hereditary; cancer ... See more keywords
Present status of germline findings in precision medicine for Japanese cancer patients: issues in the current system.
Sign Up to like & getrecommendations! Published in 2022 at "Japanese journal of clinical oncology"
DOI: 10.1093/jjco/hyac046
Abstract: OBJECTIVE Since 2019, precision cancer medicine has been covered by national insurance in Japan; however, to date, germline findings have not been fully reported. The aim of this study was to evaluate the current status… read more here.
Keywords: medicine; cancer; germline findings; germline testing ... See more keywords
Additional germline findings from a tumor profiling program
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DOI: 10.1186/s12920-018-0383-5
Abstract: BackgroundMatched tumor-normal sequencing, applied in precision cancer medicine, can identify unidentified germline Medically Actionable Variants (gMAVS) in cancer predisposition genes. We report patient preferences for the return of additional germline results, and describe various gMAV… read more here.
Keywords: additional germline; germline findings; cancer; germline ... See more keywords
Rate of incidental germline findings detected by tumor-normal matched sequencing in cancer types lacking hereditary cancer testing guidelines.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.15_suppl.10582
Abstract: 10582 Background: Up to 10% of all cancers are associated with hereditary cancer syndromes; however, guidelines for germline testing are currently limited to patients and families with specific cancer types (ovarian, breast, prostate, pancreatic, etc.).… read more here.
Keywords: incidental germline; cancer types; hereditary cancer; cancer ... See more keywords
Handling of Germline Findings in Clinical Comprehensive Cancer Genomic Profiling.
Sign Up to like & getrecommendations! Published in 2022 at "Acta medica Okayama"
DOI: 10.18926/amo/64117
Abstract: Patients found to have presumed germline pathogenic variants (PGPVs) during comprehensive genomic profiling (CGP) require genetic counseling (GC) referrals. We retrospectively investigated the outcomes of patients with PGPVs. Among 159 patients who underwent CGP, we… read more here.
Keywords: genomic profiling; patients pgpvs; handling germline; germline findings ... See more keywords