Germ-Inating Solutions or Gene-Rating Problems: An Islamic Perspective on Human Germline Gene Editing
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Religion and Health"
DOI: 10.1007/s10943-019-00770-5
Abstract: Human germline gene editing (hGGE) poses many questions for the Muslim community. They range from the scientific: is there sufficient evidence that hGGE is better than existing technologies? To the ethical: is the lack of… read more here.
Keywords: gene editing; germ inating; human germline; gene ... See more keywords
‘Eugenics is Back’? Historic References in Current Discussions of Germline Gene Editing
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DOI: 10.1007/s11569-019-00351-6
Abstract: Comparisons between germline gene editing using CRISPR technology and a renewal of eugenics are evident in the current bioethical discussions. This article examines the different roles of such references to the past. In the first… read more here.
Keywords: gene editing; eugenics back; historic references; gene ... See more keywords
Islamic Perspectives on CRISPR/Cas9-Mediated Human Germline Gene Editing: A Preliminary Discussion
Sign Up to like & getrecommendations! Published in 2020 at "Science and Engineering Ethics"
DOI: 10.1007/s11948-019-00098-z
Abstract: The recent development of CRISPR/Cas9 technology has rekindled the ethical debate concerning human germline modification that has begun decades ago. This inexpensive technology shows tremendous promise in disease prevention strategies, while raising complex ethical concerns… read more here.
Keywords: gene editing; crispr cas9; human germline; germline ... See more keywords
Germline gene-editing research needs rules
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DOI: 10.1038/d41586-019-00788-5
Abstract: In the wake of CRISPR babies, there is an urgent need to better regulate and debate whether, when and how related research should be done.In the wake of CRISPR babies, there is an urgent need… read more here.
Keywords: research; gene editing; editing research; needs rules ... See more keywords
Rare catastrophes and evolutionary legacies: human germline gene variants in MLKL and the necroptosis signalling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society Transactions"
DOI: 10.1042/bst20210517
Abstract: Programmed cell death has long been characterised as a key player in the development of human disease. Necroptosis is a lytic form of programmed cell death that is universally mediated by the effector protein mixed… read more here.
Keywords: necroptosis; human germline; germline gene; gene variants ... See more keywords
Germline gene editing and the precautionary principle
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DOI: 10.1111/bioe.12609
Abstract: Abstract The precautionary principle aims to influence decision‐making in contexts where some activity poses uncertain but potentially grave threats. This perfectly describes the controversy surrounding germline gene editing. This article considers whether the precautionary principle… read more here.
Keywords: gene editing; principle; editing precautionary; precautionary principle ... See more keywords
Gene editing and the health of future generations
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DOI: 10.1177/0141076817705616
Abstract: The CRISPR-cas9 gene-editing system (CRISPR) is a revolutionary technology that promises unparalleled abilities. It is the first technology that allows for the precise, efficient modification of DNA sequences. Less than five years since it was… read more here.
Keywords: gene editing; editing health; future generations; gene ... See more keywords
Getting serious about the challenge of regulating germline gene therapy
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DOI: 10.1371/journal.pbio.3000223
Abstract: The announcement of He Jiankui’s germline editing of human embryos has been followed by a torrent of almost universal criticism of the claim on scientific and ethical grounds. That criticism is warranted. There is little… read more here.
Keywords: challenge regulating; gene therapy; getting serious; regulating germline ... See more keywords