How germline genes promote malignancy in cancer cells
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DOI: 10.1002/bies.202200112
Abstract: Cancers often express hundreds of genes otherwise specific to germ cells, the germline/cancer (GC) genes. Here, we present and discuss the hypothesis that activation of a “germline program” promotes cancer cell malignancy. We do so… read more here.
Keywords: cancer; malignancy; genes promote; germline genes ... See more keywords
Systematic identification of factors involved in the silencing of germline genes in mouse embryonic stem cells
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad071
Abstract: Abstract In mammals, many germline genes are epigenetically repressed to prevent their illegitimate expression in somatic cells. To advance our understanding of the mechanisms restricting the expression of germline genes, we analyzed their chromatin signature… read more here.
Keywords: germline; embryonic stem; mouse embryonic; germline genes ... See more keywords