Human germline genome editing is illegal in Canada, but could it be desirable for some members of the rare disease community?
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Community Genetics"
DOI: 10.1007/s12687-019-00430-x
Abstract: Human germline genome editing may prove to be especially poignant for members of the rare disease community, many of whom are diagnosed with monogenic diseases. This community lacks broad representation in the literature surrounding genome… read more here.
Keywords: genome editing; germline genome; community; rare disease ... See more keywords
SIGAR: Inferring Features of Genome Architecture and DNA Rearrangements by Split-Read Mapping
Sign Up to like & getrecommendations! Published in 2020 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evaa147
Abstract: Abstract Ciliates are microbial eukaryotes with distinct somatic and germline genomes. Postzygotic development involves extensive remodeling of the germline genome to form somatic chromosomes. Ciliates therefore offer a valuable model for studying the architecture and… read more here.
Keywords: sigar; germline genome; dna; split read ... See more keywords
Does human germline genome editing violate human dignity? An African perspective
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Law and the Biosciences"
DOI: 10.1093/jlb/lsab002
Abstract: ABSTRACT It has been variously claimed that alterations to the human genome for reproductive purposes ought to be prohibited on the basis that doing so is contrary to human dignity. This claim leads to the… read more here.
Keywords: genome editing; dignity; germline genome; human dignity ... See more keywords
CRISPR’d babies: human germline genome editing in the ‘He Jiankui affair’*
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Law and the Biosciences"
DOI: 10.1093/jlb/lsz010
Abstract: Abstract The world was shocked in Nov. 25, 2018 by the revelation that He Jiankui had used clustered regularly interspaced short palindromic repeats (‘CRISPR’) to edit embryos—two of which had, sometime in October, become living… read more here.
Keywords: germline genome; genome editing; jiankui affair; human germline ... See more keywords