Spectrum of Hematological Malignancies in 130 Patients with Germline Predisposition Syndromes - Mayo Clinic Germline Predisposition Study
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-139050
Abstract: Introduction Germline predisposition syndromes (GPS) are inherited disorders associated with germinal aberrations that increase the risk of malignancies. While aberrations in certain genes increase the risk for all types of malignancies (Tp53, ATM, CDKN2A, CHEK2),… read more here.
Keywords: 130 patients; predisposition; germline predisposition; hematological malignancies ... See more keywords
Germline predisposition to genitourinary rhabdomyosarcoma.
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DOI: 10.21037/tau-20-76
Abstract: Multiple genetic conditions predispose to the development of rhabdomyosarcoma. Much of the literature on rhabdomyosarcoma in genetic syndromes does not sub-divide the location or the pathology of the sarcomas. Therefore, there are limited data on… read more here.
Keywords: rhabdomyosarcoma; pathology; genitourinary rhabdomyosarcoma; predisposition genitourinary ... See more keywords
Lessons From Pediatric MDS: Approaches to Germline Predisposition to Hematologic Malignancies
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.813149
Abstract: Pediatric myelodysplastic syndromes (MDS) often raise concern for an underlying germline predisposition to hematologic malignancies, referred to as germline predisposition herein. With the availability of genetic testing, it is now clear that syndromic features may… read more here.
Keywords: mds; predisposition; hematologic malignancies; predisposition hematologic ... See more keywords