Speaking genomics to parents offered germline testing for cancer predisposition: Use of a 2‐visit consent model
Sign Up to like & getrecommendations! Published in 2019 at "Cancer"
DOI: 10.1002/cncr.32071
Abstract: Patients with cancer are increasingly offered genomic sequencing, including germline testing for cancer predisposition or other disorders. Such testing is unfamiliar to patients and families, and clear communication is needed to introduce genomic concepts and… read more here.
Keywords: testing cancer; germline testing; speaking genomics; cancer predisposition ... See more keywords
Patterns of germline and somatic testing after universal tumor screening for Lynch syndrome: A clinical practice survey of active members of the Collaborative Group of the Americas on Inherited Gastrointestinal Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of genetic counseling"
DOI: 10.1002/jgc4.1567
Abstract: Clinical guidelines recommend universal tumor screening (UTS) of colorectal and endometrial cancers for Lynch syndrome (LS). There are limited guidelines for how to integrate germline testing and somatic tumor testing after a mismatch repair deficient… read more here.
Keywords: tumor; cancer; survey; germline testing ... See more keywords
Reply to Dr. Witjes regarding universal tumor genomic sequencing as a prescreen for germline genetic testing in patients diagnosed with ovarian cancer
Sign Up to like & getrecommendations! Published in 2021 at "Gynecologic Oncology Reports"
DOI: 10.1016/j.gore.2021.100843
Abstract: We would like to thank Dr. Witjes and her colleagues for their interest in our paper and for taking the time to elaborate on the promises of universal tumor genomic sequencing as a prescreen for… read more here.
Keywords: tumor; genetic testing; germline testing; tumor genomic ... See more keywords
Present status of germline findings in precision medicine for Japanese cancer patients: issues in the current system.
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DOI: 10.1093/jjco/hyac046
Abstract: OBJECTIVE Since 2019, precision cancer medicine has been covered by national insurance in Japan; however, to date, germline findings have not been fully reported. The aim of this study was to evaluate the current status… read more here.
Keywords: medicine; cancer; germline findings; germline testing ... See more keywords
Compliance with the Current NCCN Guidelines and Its Critical Role in Pancreatic Adenocarcinoma.
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DOI: 10.1093/labmed/lmac046
Abstract: OBJECTIVES Since 2019, the National Comprehensive Cancer Network (NCCN) has recommended genetic testing for patients diagnosed with pancreatic adenocarcinoma that includes universal germline testing and tumor gene profiling for metastatic, locally advanced, or recurrent disease.… read more here.
Keywords: tumor gene; germline testing; compliance; nccn guidelines ... See more keywords
Abstract 621: Germline testing in African American women with invasive breast cancer
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DOI: 10.1158/1538-7445.am2019-621
Abstract: Background: Although African ancestry is not included in the NCCN guidelines for identifying women with invasive breast cancer who may benefit from genetic testing, African American women (AAW) are at increased risk of being diagnosed… read more here.
Keywords: germline testing; genetic testing; cancer; breast cancer ... See more keywords
Abstract ES6-1: Who should have germline testing for hereditary breast cancer?
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs19-es6-1
Abstract: Who should have germline testing for hereditary breast cancer? Several guidelines exist for who should be offered germline testing for mutations in breast and ovarian cancer susceptibility genes. NCCN guidelines currently recommend germline BRCA testing… read more here.
Keywords: breast cancer; germline testing; brca; cancer ... See more keywords
Confirmation of germline variants identified by tumor testing: A population-based study.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e13021
Abstract: e13021 Background: Multi-gene panel tumour testing (TT) has been available in British Columbia since mid-2016 for metastatic non-small cell lung cancer (NSCLC), colorectal cancer (CRC), melanoma (MEL), low-grade glioma (LGG), and gastro-intestinal stromal tumours (GIST).… read more here.
Keywords: germline; hereditary cancer; cancer; confirmation germline ... See more keywords
Changing the landscape of germline testing in patients with pancreatic adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.4_suppl.676
Abstract: 676Background: Results from the POLO trial demonstrated the benefits of PARP inhibition in patients (pts) with germline BRCA-mutated metastatic pancreatic cancer (PC). In 2018, ASCO and NCCN update... read more here.
Keywords: testing patients; landscape germline; pancreatic adenocarcinoma; germline testing ... See more keywords
Circulating tumor DNA (ctDNA) as a tool to help guide germline testing in patients with solid malignancies.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.15_suppl.10602
Abstract: 10602 Background: As the use of circulating tumor DNA (ctDNA) is more widely implemented, incidental identification of pathogenic variants reflecting germline alterations in cancer predisposition genes will occur more frequently. Such mutations are expected to… read more here.
Keywords: testing patients; germline; high maf; germline testing ... See more keywords
Germline testing in community oncology patients with somatic BRCA1/2 mutations.
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DOI: 10.1200/jco.2021.39.15_suppl.1523
Abstract: 1523 Background: The primary purpose of tumor mutation profiling (TMP) is to molecularly characterize tumors to identify targeted treatments and improve outcomes, but it may also uncover germline mutations with implications for patients and families.… read more here.
Keywords: somatic brca1; germline testing; patients somatic; oncology ... See more keywords