Cancer-driving mutations are enriched in genic regions intolerant to germline variation
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1101/2022.01.07.475416
Abstract: Large reference datasets of protein-coding variation in human populations have allowed us to determine which genes and genic sub-regions are intolerant to germline genetic variation. There is also a growing number of genes implicated in… read more here.
Keywords: germline variation; cancer driving; variation; regions intolerant ... See more keywords
Germline variation of circadian pathway genes and prognosis of gastric cancer patients
Sign Up to like & getrecommendations! Published in 2018 at "Gut"
DOI: 10.1136/gutjnl-2017-314740
Abstract: As we have summarised in this journal,1 germline DNA variation has been long recognised as a key component of the risk to develop to gastric carcinoma, the discovery pace being greatly accelerated by genome-wide association… read more here.
Keywords: germline variation; variation; gastric cancer; prognosis ... See more keywords