Mid-Gestation lethality of Atxn2l-Ablated Mice
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DOI: 10.3390/ijms21145124
Abstract: Depletion of yeast/fly Ataxin-2 rescues TDP-43 overexpression toxicity. In mouse models of Amyotrophic Lateral Sclerosis via TDP-43 overexpression, depletion of its ortholog ATXN2 mitigated motor neuron degeneration and extended lifespan from 25 days to >300… read more here.
Keywords: atxn2l ablated; gestation lethality; mid gestation; lethality atxn2l ... See more keywords