PREDICT‐GTN 1: Can we improve the FIGO scoring system in gestational trophoblastic neoplasia?
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34352
Abstract: Gestational trophoblastic neoplasia (GTN) patients are treated according to the eight‐variable International Federation of Gynaecology and Obstetrics (FIGO) scoring system, that aims to predict first‐line single‐agent chemotherapy resistance. FIGO is imperfect with one‐third of low‐risk… read more here.
Keywords: figo scoring; trophoblastic neoplasia; scoring system; gestational trophoblastic ... See more keywords
Versican silencing in BeWo cells and its implication in gestational trophoblastic diseases
Sign Up to like & getrecommendations! Published in 2018 at "Histochemistry and Cell Biology"
DOI: 10.1007/s00418-018-1739-9
Abstract: Versican is a proteoglycan known to interact with cells to influence their ability to proliferate, differentiate, migrate, invade and assemble extracellular matrix, with all of these cell functions present during placentation. In the placenta, cytotrophoblast… read more here.
Keywords: trophoblastic diseases; silencing bewo; bewo cells; gestational trophoblastic ... See more keywords
Distinct microRNA profiles for complete hydatidiform moles at risk for malignant progression.
Sign Up to like & getrecommendations! Published in 2020 at "American journal of obstetrics and gynecology"
DOI: 10.1016/j.ajog.2020.09.048
Abstract: BACKGROUND MicroRNAs (miRNAs) are small non-coding RNAs with important regulatory functions. While well-studied in cancer, less is known about the role of miRNAs in premalignant disease. Complete hydatidiform moles are benign forms of gestational trophoblastic… read more here.
Keywords: ontology; expression; gestational trophoblastic; complete moles ... See more keywords
Hypothesis on the possible relevance of the immunogenic cell death in the treatment of gestational trophoblastic neoplasms
Sign Up to like & getrecommendations! Published in 2021 at "Translational Oncology"
DOI: 10.1016/j.tranon.2021.101224
Abstract: The genetic background and the antigenic landscape of cancer cells play a critical role in the response to immunotherapies. A high tumor antigenicity, together with an increased adjuvanticity potentially induced by a peculiar type of… read more here.
Keywords: immunogenic cell; hypothesis possible; gestational trophoblastic; cell death ... See more keywords
15years of progress in gestational trophoblastic disease: Scoring, standardization, and salvage.
Sign Up to like & getrecommendations! Published in 2017 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2016.08.330
Abstract: Significant improvements in treatment and the understanding of gestational trophoblastic neoplasia have occurred in the last 15years. These diseases are almost always curable, and refractory patients have more options for salvage therapy. Recent improvements in… read more here.
Keywords: 15years progress; progress gestational; scoring standardization; gestational trophoblastic ... See more keywords
Salvage chemotherapy for gestational trophoblastic neoplasia: Utility or futility?
Sign Up to like & getrecommendations! Published in 2017 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2017.04.017
Abstract: OBJECTIVE To determine the efficacy of chemotherapy after failed initial treatment in patients with high risk gestational trophoblastic neoplasia (GTN). METHODS We performed a retrospective IRB-approved chart review of all patients with GTN seen at… read more here.
Keywords: pfs; salvage chemotherapy; salvage; gestational trophoblastic ... See more keywords
Heterozygous/dispermic complete mole confers a significantly higher risk for post-molar gestational trophoblastic disease
Sign Up to like & getrecommendations! Published in 2020 at "Modern Pathology"
DOI: 10.1038/s41379-020-0566-4
Abstract: Hydatidiform moles are classified at the genetic level as androgenetic complete mole and diandric-monogynic partial mole. Conflicting data exist whether heterozygous complete moles are more aggressive clinically than homozygous complete moles. We investigated clinical outcome… read more here.
Keywords: molar gestational; gestational trophoblastic; trophoblastic disease; post molar ... See more keywords
Gestational trophoblastic disease- rare, sometimes dramatic, and what we know so far.
Sign Up to like & getrecommendations! Published in 2022 at "Seminars in diagnostic pathology"
DOI: 10.1053/j.semdp.2022.03.002
Abstract: Gestational trophoblastic disease (GTD) is a heterogeneous group of lesions that are characterized by the abnormal proliferation of the trophoblast. Morphology, behavior and clinical significance vary tremendously and range from benign, non-neoplastic lesions that cause… read more here.
Keywords: trophoblastic disease; gestational trophoblastic; disease rare; rare sometimes ... See more keywords
Gestational and Non-gestational Trophoblastic Neoplasia. Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry No. 032/049, April 2022)
Sign Up to like & getrecommendations! Published in 2022 at "Geburtshilfe und Frauenheilkunde"
DOI: 10.1055/a-1904-6461
Abstract: Abstract Purpose The aim was to develop and update a guideline which would improve the quality of care offered to women with gestational and non-gestational trophoblastic disease, a group of diseases characterized by their rarity… read more here.
Keywords: non gestational; trophoblastic disease; guideline; gestational trophoblastic ... See more keywords
Current chemotherapeutic options for the treatment of gestational trophoblastic disease
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2022.2150075
Abstract: ABSTRACT Introduction Gestational trophoblastic neoplasia (GTN) is a rare tumor that arises from trophoblastic tissues with high remission rates after chemotherapy treatment. GTN can develop from any gestational events, such as miscarriage, ectopic pregnancy, and… read more here.
Keywords: disease; gestational trophoblastic; gtn; treatment ... See more keywords
The optimal management of brain metastases from gestational trophoblastic neoplasia
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Anticancer Therapy"
DOI: 10.1080/14737140.2022.2038566
Abstract: ABSTRACT Introduction Gestational trophoblastic diseases and neoplasias (GTDs and GTNs) comprise a spectrum of diseases arising from abnormally proliferating placental/trophoblastic tissue following an antecedent molar or non-molar pregnancy. These can spread to the brain hematogenously… read more here.
Keywords: brain metastases; trophoblastic neoplasia; optimal management; gestational trophoblastic ... See more keywords