Getting a Handle on Neuropharmacology by Targeting Receptor-Associated Proteins
Sign Up to like & getrecommendations! Published in 2017 at "Neuron"
DOI: 10.1016/j.neuron.2017.10.001
Abstract: Targeted therapy for neuropsychiatric disorders requires selective modulation of dysfunctional neuronal pathways. Receptors relevant to CNS disorders typically have associated proteins discretely expressed in specific neuronal pathways; these accessory proteins provide a new dimension for… read more here.
Keywords: associated proteins; handle neuropharmacology; getting handle; neuropharmacology targeting ... See more keywords
Getting a handle on chemical probes of chomatin readers.
Sign Up to like & getrecommendations! Published in 2020 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2019-0274
Abstract: The dynamic nature of histone post-translational modifications such as methylation or acetylation makes possible the alteration of disease associated epigenetic states through the manipulation of the associated epigenetic machinery. One approach is through small molecule… read more here.
Keywords: handle chemical; probes chomatin; chomatin readers; chemical ... See more keywords