Gfi1‐GCE inducible Cre line for hair cell‐specific gene manipulation in mouse inner ear
Sign Up to like & getrecommendations! Published in 2019 at "genesis"
DOI: 10.1002/dvg.23304
Abstract: Tissue‐specific inducible Cre recombinase mouse lines allow precise genetic manipulations in spatiotemporal manners and are pivotal for functional studies of genes during development and in adults. Growth factor independence 1 (GFI1) is an essential transcription… read more here.
Keywords: inner ear; hair; gfi1; gfi1 gce ... See more keywords
Generation of a GFI1-flag knock-in human embryonic stem cell line using CRISPR-Cas9 technology.
Sign Up to like & getrecommendations! Published in 2022 at "Stem cell research"
DOI: 10.1016/j.scr.2022.102724
Abstract: GFI1 is a DNA binding transcriptional repressor, it is shown to be an important gene associated with blood cells development and many blood diseases (Möröy et al., 2015). But the role of GFI1 in human… read more here.
Keywords: stem cell; cell line; cell; gfi1 ... See more keywords
Combinatorial Atoh1 and Gfi1 induction enhances hair cell regeneration in the adult cochlea
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-78167-8
Abstract: Mature mammalian cochlear hair cells (HCs) do not spontaneously regenerate once lost, leading to life-long hearing deficits. Attempts to induce HC regeneration in adult mammals have used over-expression of the HC-specific transcription factor Atoh1, but… read more here.
Keywords: adult; regeneration; gfi1; expression ... See more keywords
SCFFBXW7/GSK3β-mediated GFI1 degradation suppresses gastric cancer cell proliferation.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer research"
DOI: 10.1158/0008-5472.can-18-4032
Abstract: Gastric cancer (GC) is the third leading cause of cancer-related death worldwide. The regulatory mechanisms underlying GC cell proliferation are largely unclear. Here, we showed that the transcription factor GFI1 is associated with advanced clinical… read more here.
Keywords: gastric cancer; cell proliferation; gfi1; cancer ... See more keywords
Growth Factor–Independent 1 Is a Tumor Suppressor Gene in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-18-0666
Abstract: Colorectal cancer is the third most common cancer and the third leading cause of cancer death in the United States. Growth factor–independent 1 (GFI1) is a zinc finger transcriptional repressor responsible for controlling secretory cell… read more here.
Keywords: suppressor gene; cancer; gfi1; tumor suppressor ... See more keywords
IFNγ suppresses the expression of GFI1 and thereby inhibits Th2 cell proliferation
Sign Up to like & getrecommendations! Published in 2021 at "PLoS ONE"
DOI: 10.1371/journal.pone.0260204
Abstract: While IFNγ is a well-known cytokine that actively promotes the type I immune response, it is also known to suppress the type II response by inhibiting the differentiation and proliferation of Th2 cells. However, the… read more here.
Keywords: cell proliferation; proliferation; gfi1; th2 ... See more keywords
Dose-dependent effect of GFI1 expression in the reconstitution and the differentiation capacity of HSCs
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.866847
Abstract: GFI1 is a transcriptional repressor and plays a pivotal role in regulating the differentiation of hematopoietic stem cells (HSCs) towards myeloid and lymphoid cells. Serial transplantation of Gfi1 deficient HSCs repopulated whole hematopoietic system but… read more here.
Keywords: gfi1 hscs; hscs; gfi1; expression ... See more keywords
GFI1-Dependent Repression of SGPP1 Increases Multiple Myeloma Cell Survival
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14030772
Abstract: Simple Summary New therapies have greatly improved the progression-free and overall survival for patients with “standard risk” multiple myeloma (MM). However, patients with “high risk” MM, in particular patients whose MM cells harbor non-functional p53,… read more here.
Keywords: gfi1; survival; p53; multiple myeloma ... See more keywords