Contribution of autophagy to ocular hypertension and neurodegeneration in the DBA/2J spontaneous glaucoma mouse model
Sign Up to like & getrecommendations! Published in 2018 at "Cell Death Discovery"
DOI: 10.1038/s41420-018-0077-y
Abstract: Glaucoma is a progressive optic neuropathy characterized by axonal degeneration and retinal ganglion cells loss. Several factors have been postulated to play a role in glaucoma, elevated intraocular pressure (IOP) being the best well-known causative… read more here.
Keywords: ocular hypertension; glaucoma; model; dba ... See more keywords
Mitochondrial depolarization after acute ethanol treatment drives mitophagy in living mice
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2046457
Abstract: ABSTRACT Ethanol increases hepatic mitophagy driven by unknown mechanisms. Type 1 mitophagy sequesters polarized mitochondria for nutrient recovery and cytoplasmic remodeling. In Type 2, mitochondrial depolarization (mtDepo) initiates mitophagy to remove the damaged organelles. Previously,… read more here.
Keywords: mitochondrial depolarization; treatment; ethanol treatment; gfp lc3 ... See more keywords