Rational engineering of a human GFP-like protein scaffold for humanized targeted nanomedicines.
Sign Up to like & getrecommendations! Published in 2021 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2021.06.001
Abstract: Green fluorescent protein (GFP) is a widely used scaffold for protein-based targeted nanomedicines because of its high biocompatibility, biological neutrality and outstanding structural stability. However, being immunogenicity a major concern in the development of drug… read more here.
Keywords: protein; protein scaffold; gfp like; like protein ... See more keywords
New findings on GFP-like protein application as fluorescent tags: Fibrillogenesis, oligomerization, and amorphous aggregation.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.10.107
Abstract: Green fluorescent proteins (GFP) are commonly used as fluorescent tags and biosensors in cell biology and medicine. However, the propensity of GFP-like proteins to aggregate and the consequence of intermolecular interaction for their application have… read more here.
Keywords: protein; aggregation; gfp like; fluorescent ... See more keywords
Structural Factors Enabling Successful GFP-Like Proteins with Alanine as the Third Chromophore-Forming Residue.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Biology"
DOI: 10.2210/pdb6mas/pdb
Abstract: GFP-like proteins from lancelets (lanFPs) is a new and least studied group that already generated several outstanding biomarkers (mNeonGreen is the brightest FP to date) and has some unique features. Here, we report the study… read more here.
Keywords: like proteins; third chromophore; chromophore forming; chromophore ... See more keywords