GFPT1 promotes the proliferation of cervical cancer via regulating the ubiquitination and degradation of PTEN.
Sign Up to like & getrecommendations! Published in 2022 at "Carcinogenesis"
DOI: 10.1093/carcin/bgac073
Abstract: Cervical cancer demonstrates the fourth incidence and death rate in female worldwide. Glutamine--fructose-6-phosphate transaminase 1 (GFPT1), the first rate-limited enzyme of hexosamine biosynthesis pathway, has been reported to promote the progression of cancers. However, the… read more here.
Keywords: cervical cancer; proliferation cervical; ubiquitination degradation; gfpt1 ... See more keywords
GFPT1 accelerates immune escape in breast cancer by modifying PD-L1 via O-glycosylation
Sign Up to like & getrecommendations! Published in 2024 at "BMC Cancer"
DOI: 10.1186/s12885-024-12811-8
Abstract: Immune escape is one of the causes of poor prognosis in breast cancer (BC). Glutamine-fructose-6-phosphate transaminase 1 (GFPT1) is the first speed-limiting enzyme of the hexosamine biosynthesis pathway (HBP) and is essential for the progression… read more here.
Keywords: breast cancer; gfpt1; immune escape; glycosylation ... See more keywords