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   Articles with "ggc" as a keyword



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GGC repeat expansions in NOTCH2NLC causing a phenotype of lower motor neuron syndrome

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recommendations! Published in 2022 at "Journal of Neurology"

DOI: 10.1007/s00415-022-11092-0

Abstract: A genetic diagnosis cannot be made in a considerable proportion of patients with hereditary lower motor neuron (LMN) syndromes. The GGC repeat expansion in the 5′untranslated region (5′UTR) of NOTCH2NLC gene has been reported to… read more here.

Keywords: ggc repeat; phenotype; lower motor; ggc ... See more keywords
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Gamma-glutamylcysteine protects ergothioneine-deficient Mycobacterium tuberculosis mutants against oxidative and nitrosative stress.

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recommendations! Published in 2018 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2017.10.163

Abstract: Mycobacterium tuberculosis (M.tb.), the causative agent of tuberculosis (TB), cannot synthesize GSH, but synthesizes two major low molecular weight thiols namely mycothiol (MSH) and ergothioneine (ERG). Gamma-glutamylcysteine (GGC), an intermediate in GSH synthesis, has been… read more here.

Keywords: deficient; gamma glutamylcysteine; stress; ggc ... See more keywords
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The functional interplay of low molecular weight thiols in Mycobacterium tuberculosis

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recommendations! Published in 2018 at "Journal of Biomedical Science"

DOI: 10.1186/s12929-018-0458-9

Abstract: BackgroundThree low molecular weight thiols are synthesized by Mycobacterium tuberculosis (M.tb), namely ergothioneine (ERG), mycothiol (MSH) and gamma-glutamylcysteine (GGC). They are able to counteract reactive oxygen species (ROS) and/or reactive nitrogen species (RNS). In addition,… read more here.

Keywords: low molecular; molecular weight; erg; tuberculosis ... See more keywords
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The Precursor to Glutathione (GSH), γ-Glutamylcysteine (GGC), Can Ameliorate Oxidative Damage and Neuroinflammation Induced by Aβ40 Oligomers in Human Astrocytes

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recommendations! Published in 2019 at "Frontiers in Aging Neuroscience"

DOI: 10.3389/fnagi.2019.00177

Abstract: Glutathione (GSH) is one of the most abundant thiol antioxidants in cells. Many chronic and age-related diseases are associated with a decline in cellular GSH levels or impairment in the catalytic activity of the GSH… read more here.

Keywords: gsh; human astrocytes; glutathione gsh; ggc ... See more keywords