Vitamin K2-Dependent GGCX and MGP Are Required for Homeostatic Calcium Regulation of Sperm Maturation
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DOI: 10.1016/j.isci.2019.03.030
Abstract: Summary A low-calcium microenvironment is essential for spermatozoa to mature in the epididymis; however, it remains unclear how dysregulation of epididymal luminal calcium is associated with male infertility. Using a warfarin-induced vitamin K2 deficiency rat… read more here.
Keywords: calcium; ggcx mgp; sperm maturation; ggcx ... See more keywords
Impact of VKORC1, CYP2C9, CYP1A2, UGT1A1, and GGCX polymorphisms on warfarin maintenance dose: Exploring a new algorithm in South Chinese patients accept mechanical heart valve replacement
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000029626
Abstract: Background: Warfarin is the most recommended oral anticoagulant after artificial mechanical valve replacement therapy. However, the narrow therapeutic window and varying safety and efficacy in individuals make dose determination difficult. It may cause adverse events… read more here.
Keywords: maintenance dose; valve replacement; dose; ggcx ... See more keywords
GGCX mutants that impair hemostasis reveal the importance of processivity and full carboxylation to VKD protein function.
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DOI: 10.1182/blood.2021014275
Abstract: The gamma-glutamyl carboxylase (GGCX) generates multiple carboxylated Glus (Glas) in vitamin K-dependent (VKD) proteins that are required for their functions. GGCX is processive, remaining bound to VKD proteins throughout the multiple Glu carboxylations, and this… read more here.
Keywords: vkd protein; vkd; carboxylation; processivity ... See more keywords
Multiple Modes of Vitamin K Actions in Aging-Related Musculoskeletal Disorders
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DOI: 10.3390/ijms20112844
Abstract: Vitamin K is a fat-soluble vitamin that was originally found as an essential factor for blood coagulation. With the discovery of its role as a co-factor for γ-glutamyl carboxylase (GGCX), its function for blood coagulation… read more here.
Keywords: modes vitamin; aging related; vitamin; related musculoskeletal ... See more keywords