Cholesterol metabolic enzyme Ggpps regulates epicardium development and ventricular wall architecture integrity in mice
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DOI: 10.1093/jmcb/mjab019
Abstract: Abstract During embryonic heart development, the progenitor cells in the epicardium would migrate and differentiate into noncardiomyocytes in myocardium and affect the integrity of ventricular wall, but the underlying mechanism has not been well studied.… read more here.
Keywords: ventricular wall; cholesterol; integrity; wall ... See more keywords
Geranylgeranyl diphosphate synthase deficiency aggravates lung fibrosis in mice by modulating TGF-β1/BMP-4 signaling
Sign Up to like & getrecommendations! Published in 2019 at "Biological Chemistry"
DOI: 10.1515/hsz-2019-0168
Abstract: Abstract Geranylgeranyl diphosphate synthase (GGPPS) is an enzyme that catalyzes the synthesis of geranylgeranyl pyrophosphate (GGPP). GGPPS is implicated in many disorders, but its role in idiopathic pulmonary fibrosis (IPF) remains unclear. This study aimed… read more here.
Keywords: geranylgeranyl diphosphate; fibrosis; ggpps; mice ... See more keywords