The role of chirality in a set of key intermediates of pharmaceutical interest, 3‐aryl‐substituted‐&ggr;‐butyrolactones, evidenced by chiral HPLC separation and by chiroptical spectroscopies
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DOI: 10.1016/j.jpba.2017.01.007
Abstract: HIGHLIGHTSHPLC Separation of enantiomers of four 3‐aryl‐substituted‐&ggr;‐butyrolactones (3AGBL).ECD, ORD, and VCD of four 3AGBL. Similarity indexes calculated for VCD and ECD.From AD‐H columns (S) enantiomers of 3AGBL elute before (R) enantiomers.Molecular Docking explains elution order.Lactone‐chirality… read more here.
Keywords: substituted ggr; pharmaceutical interest; aryl substituted; key intermediates ... See more keywords