Exchange proteins directly activated by cAMP induce the proliferation of rat anterior pituitary GH3 cells via the activation of extracellular signal-regulated kinase.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.02.075
Abstract: Cyclic adenosine 3'-5'-monophosphate (cAMP) plays a crucial role in regulating pituitary cell proliferation and hormone synthesis. Recent evidence suggests that exchange proteins directly activated by cAMP (Epacs) may mediate the effects of cAMP. Here we… read more here.
Keywords: camp; proliferation; gh3 cells; exchange proteins ... See more keywords
Regulatory role of melatonin and BMP-4 in prolactin production by rat pituitary lactotrope GH3 cells
Sign Up to like & getrecommendations! Published in 2017 at "Peptides"
DOI: 10.1016/j.peptides.2017.06.001
Abstract: HIGHLIGHTSMelatonin receptor activation suppresses PRL expression and secretion by lactotrope GH3 cells.MT2 activation regulates PRL level by suppressing cAMP, BMP‐Smad and ERK pathways.BMP‐4 induces PRL expression but also upregulates MT2 as a possible feedback loop.… read more here.
Keywords: melatonin; prolactin production; bmp; gh3 cells ... See more keywords
Fulvestrant inhibits the glycolysis of prolactinoma GH3 cells by downregulating IRE1/XBP1 signaling pathway.
Sign Up to like & getrecommendations! Published in 2018 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_201808_15739
Abstract: OBJECTIVE We aimed to evaluate the effects of fulvestrant on the glycolysis of prolactinoma GH3 cells, and reveal the potential regulatory mechanisms. MATERIALS AND METHODS Prolactinoma cell line GH3 was treated with different concentrations of… read more here.
Keywords: xbp1s xbp1u; gh3 cells; cells downregulating; prolactinoma gh3 ... See more keywords
Characterization of Stimulatory Action on Voltage-Gated Na+ Currents Caused by Omecamtiv Mecarbil, Known to Be a Myosin Activator
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11051351
Abstract: Omecamtiv mecarbil (OM, CK-1827452) is recognized as an activator of myosin and has been demonstrated to be beneficial for the treatment of systolic heart failure. However, the mechanisms by which this compound interacts with ionic… read more here.
Keywords: omecamtiv mecarbil; voltage gated; ina; voltage ... See more keywords
Modulation of INa, Ih, and IK(erg) by Extracellular or Intracellular QX-314 (N-(2,6-dimethylphenylcarbamoylmethyl) triethylammonium bromide) in Pituitary Tumor Cells
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms26178469
Abstract: QX-314 is a positively charged lidocaine derivative with the membrane-impermeant property. This compound applied at the intracellular side has been shown to suppress the voltage-gated Na+ current (INa), while lidocaine itself acts to suppress the… read more here.
Keywords: erg extracellular; extracellular intracellular; gh3 cells; ina erg ... See more keywords