Ghrelin Bridges DMV Neuropathology and GI Dysfunction in the Early Stages of Parkinson's Disease
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202203020
Abstract: Ghrelin contributes to the communication between the brain and gastrointestinal (GI) tract. Both decreased ghrelin levels and functional GI disorders are early events in Parkinson's disease (PD) patients and animal models. However, the reason is… read more here.
Keywords: ghrelin levels; parkinson disease; ghrelin; dysfunction ... See more keywords
Ghrelin ameliorates chronic obstructive pulmonary disease–associated infllammation and autophagy
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.1933
Abstract: Chronic obstructive pulmonary disease (COPD) is a chronic and devastating condition characterized by poor airflow and breath. Smoking and other environmental factors–caused inflammations triggered excessive autophagy of normal lung epithelial cells, eventually leading to impaired… read more here.
Keywords: chronic obstructive; obstructive pulmonary; autophagy; pulmonary disease ... See more keywords
Ghrelin modulates intracellular signalling pathways that are critical for podocyte survival
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3397
Abstract: Damage to podocytes is a key event in glomerulopathies. While energy dense food can contribute to kidney damage, the role of the orixegenic hormone “ghrelin” in podocyte biology is still unknown. In the present study,… read more here.
Keywords: p38 mapk; podocyte survival; ghrelin;
The effect of glutamate on ghrelin release in mice
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DOI: 10.1002/cbin.10728
Abstract: Ghrelin is abundantly produced in the stomach. Here, we found that glutamate decreased ghrelin expression and release in ghrelin‐producing cells, and decreased levels of food intake and plasma acyl‐ghrelin in mice. Treatment with siRNA of… read more here.
Keywords: effect glutamate; mice; ghrelin release; glutamate ... See more keywords
Ghrelin regulates the proliferation and apoptosis of high glucose‐induced islet cells through the PI3K–Akt signaling pathway
Sign Up to like & getrecommendations! Published in 2023 at "Cell Biology International"
DOI: 10.1002/cbin.11981
Abstract: Ghrelin may have therapeutic value in mitigating insulin resistance and type 2 diabetes, based on which we further explore the action mechanism of ghrelin on islet cells in this research. In the course of experiments,… read more here.
Keywords: pi3k akt; islet cells; akt signaling; ghrelin ... See more keywords
Elevated ghrelin alters the behavioral effects of perinatal acetaminophen exposure in rats.
Sign Up to like & getrecommendations! Published in 2022 at "Developmental psychobiology"
DOI: 10.1002/dev.22252
Abstract: A growing body of evidence links prenatal and early postnatal acetaminophen (APAP) exposure to atypical development of brain and behavior. In adult rodents, APAP is known to produce oxidative stress and lower anxiety-related behavior following… read more here.
Keywords: apap; effects perinatal; ghrelin; exposure rats ... See more keywords
EXT418, a novel long‐acting ghrelin, mitigates Lewis lung carcinoma induced cachexia in mice
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13211
Abstract: Ghrelin is a potential therapy for cachexia due to its orexigenic properties and anabolic effects on muscle and fat. However, its clinical use is limited by the short half‐life of active (acylated) ghrelin (~11 min… read more here.
Keywords: lung carcinoma; ext418 novel; novel long; lewis lung ... See more keywords
Assessments of plasma ghrelin levels in the early stages of parkinson's disease
Sign Up to like & getrecommendations! Published in 2017 at "Movement Disorders"
DOI: 10.1002/mds.27095
Abstract: Gastrointestinal symptoms are early events in Parkinson's disease (PD). The gastrointestinal hormone ghrelin was neuroprotective in the nigrostriatal dopamine system. The objective of this study was to assess ghrelin levels in the early stages of… read more here.
Keywords: assessments plasma; parkinson disease; early stages; levels early ... See more keywords
Stapled ghrelin peptides as fluorescent imaging probes
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DOI: 10.1002/pep2.24055
Abstract: Fluorescently labelled ghrelin is an effective imaging probe for ex vivo biopsy analysis, in vivo distribution studies, and cell‐based analyses. The objective of our study was to improve the receptor affinity and stability of this… read more here.
Keywords: fluorescent imaging; ghrelin peptides; receptor; peptides fluorescent ... See more keywords
Identification, chemical synthesis, and receptor binding of a reptilian gecko ghrelin
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Peptide Science"
DOI: 10.1002/psc.3567
Abstract: Ghrelin is known to be a gastrointestinal peptide hormone in vertebrates. It has a unique posttransrational modification, octanoylation, at the Ser side chain of the third position. In this study, we identified the genes encoding… read more here.
Keywords: gecko; receptor; ghrelin; gecko ghrelin ... See more keywords
Ferulic Acid Alleviates Traumatic Brain Injury and Gastrointestinal Disorders by Promoting Ghrelin to Regulate the Microbiota‐Brain‐Gut Axis Inflammation and Pyroptosis
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DOI: 10.1002/ptr.8450
Abstract: Traumatic brain injury (TBI) is a severe condition with a high mortality rate, affecting multiple organs, including the gastrointestinal (GI) tract. Ghrelin is a brain‐gut peptide that regulates the microbiota‐brain‐gut axis, facilitating communication between the… read more here.
Keywords: gut axis; brain; ghrelin; brain gut ... See more keywords