Behavioural characterization of ghrelin ligands, anamorelin and HM01: Appetite and reward-motivated effects in rodents
Sign Up to like & getrecommendations! Published in 2020 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2020.108011
Abstract: The ghrelinergic system has been steadily investigated as a therapeutic target in the treatment of metabolic disorders and modulation of appetite. While endogenous ghrelin activates the full complement of the growth hormone secretagogue receptor (GHSR-1a)… read more here.
Keywords: ghsr ligands; anamorelin hm01; characterization; ghsr ... See more keywords
Structure-Activity Relationships of Azaquinazolinone Derivatives as 18F-Labeled PET Probes Targeting Ghrelin Receptors.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.5c01070
Abstract: The ghrelin receptor (GHSR) is expressed in various organs including the brain, pancreas, stomach, and intestine, and is involved in many physiological functions. In vivo imaging of GHSR with positron emission tomography (PET) is expected… read more here.
Keywords: ghsr; pet probes; azaquinazolinone derivatives; pet ... See more keywords
The Pathologic Roles and Therapeutic Implications of Ghrelin/GHSR System in Mental Disorders
Sign Up to like & getrecommendations! Published in 2024 at "Depression and Anxiety"
DOI: 10.1155/2024/5537319
Abstract: Ghrelin is a hormone consisting of 28 amino acids. Growth hormone secretagogue receptor (GHSR) is a receptor for ghrelin, which is expressed in the brain, pituitary gland, and adrenal glands, especially in the hypothalamus. The… read more here.
Keywords: ghsr; system; roles therapeutic; ghrelin ... See more keywords
GHSR in a subset of GABA neurons controls food deprivation-induced hyperphagia in male mice.
Sign Up to like & getrecommendations! Published in 2024 at "Endocrinology"
DOI: 10.1210/endocr/bqae061
Abstract: The growth hormone secretagogue receptor (GHSR), primarily known as the receptor for the hunger hormone ghrelin, potently controls food intake, yet the specific Ghsr-expressing cells mediating the orexigenic effects of this receptor remain incompletely characterized.… read more here.
Keywords: mice; ghsr; food; gaba neurons ... See more keywords
SAT-167 Intra-Islet Ghrelin Signaling Does Not Regulate Insulin Secretion from Adult Mice
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-sat-167
Abstract: Abstract Ghrelin is a 28-peptide hormone that was originally discovered as a ligand for the growth hormone secretagogue receptor (GHSR) and noted for its roles in food intake and feeding behavior. Beyond this, ghrelin may… read more here.
Keywords: insulin secretion; ghsr; tolerance; ghrelin ... See more keywords
Ghrelin Receptor Is Required for the Effect of Nesfatin-1 on Glucose Metabolism
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2018.00633
Abstract: Studies of nesfatin-1 in glucose metabolism have become a topic of interest recently, however, the specific receptor for nesfatin-1 has not yet been identified. Some studies hinted at a connection between nesfatin-1 and the ghrelin… read more here.
Keywords: nesfatin glucose; glucose metabolism; nesfatin; receptor ... See more keywords
Neuronal ablation of GHSR mitigates diet-induced depression and memory impairment via AMPK-autophagy signaling-mediated inflammation
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2024.1339937
Abstract: Obesity is associated with chronic inflammation in the central nervous system (CNS), and neuroinflammation has been shown to have detrimental effects on mood and cognition. The growth hormone secretagogue receptor (GHSR), the biologically relevant receptor… read more here.
Keywords: ghsr; neuronal ghsr; diet induced; autophagy signaling ... See more keywords
Mechanistic Investigation of GHS-R Mediated Glucose-Stimulated Insulin Secretion in Pancreatic Islets
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12030407
Abstract: Ghrelin receptor, a growth hormone secretagogue receptor (GHS-R), is expressed in the pancreas. Emerging evidence indicates that GHS-R is involved in the regulation of glucose-stimulated insulin secretion (GSIS), but the mechanism by which GHS-R regulates… read more here.
Keywords: ghsr; gsis; glucose stimulated; pancreatic islets ... See more keywords
Deletion of Growth Hormone Secretagogue Receptor in Kisspeptin Neurons in Female Mice Blocks Diet-Induced Obesity
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12101370
Abstract: The gut peptide, ghrelin, mediates energy homeostasis and reproduction by acting through its receptor, growth hormone secretagogue receptor (GHSR), expressed in hypothalamic neurons in the arcuate (ARC). We have shown 17β-estradiol (E2) increases Ghsr expression… read more here.
Keywords: ghsr; ghrelin; growth hormone; secretagogue receptor ... See more keywords