Behavioural characterization of ghrelin ligands, anamorelin and HM01: Appetite and reward-motivated effects in rodents
Sign Up to like & getrecommendations! Published in 2020 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2020.108011
Abstract: The ghrelinergic system has been steadily investigated as a therapeutic target in the treatment of metabolic disorders and modulation of appetite. While endogenous ghrelin activates the full complement of the growth hormone secretagogue receptor (GHSR-1a)… read more here.
Keywords: ghsr ligands; anamorelin hm01; characterization; ghsr ... See more keywords
SAT-167 Intra-Islet Ghrelin Signaling Does Not Regulate Insulin Secretion from Adult Mice
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-sat-167
Abstract: Abstract Ghrelin is a 28-peptide hormone that was originally discovered as a ligand for the growth hormone secretagogue receptor (GHSR) and noted for its roles in food intake and feeding behavior. Beyond this, ghrelin may… read more here.
Keywords: insulin secretion; ghsr; tolerance; ghrelin ... See more keywords
Ghrelin Receptor Is Required for the Effect of Nesfatin-1 on Glucose Metabolism
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2018.00633
Abstract: Studies of nesfatin-1 in glucose metabolism have become a topic of interest recently, however, the specific receptor for nesfatin-1 has not yet been identified. Some studies hinted at a connection between nesfatin-1 and the ghrelin… read more here.
Keywords: nesfatin glucose; glucose metabolism; nesfatin; receptor ... See more keywords
Mechanistic Investigation of GHS-R Mediated Glucose-Stimulated Insulin Secretion in Pancreatic Islets
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12030407
Abstract: Ghrelin receptor, a growth hormone secretagogue receptor (GHS-R), is expressed in the pancreas. Emerging evidence indicates that GHS-R is involved in the regulation of glucose-stimulated insulin secretion (GSIS), but the mechanism by which GHS-R regulates… read more here.
Keywords: ghsr; gsis; glucose stimulated; pancreatic islets ... See more keywords
Deletion of Growth Hormone Secretagogue Receptor in Kisspeptin Neurons in Female Mice Blocks Diet-Induced Obesity
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12101370
Abstract: The gut peptide, ghrelin, mediates energy homeostasis and reproduction by acting through its receptor, growth hormone secretagogue receptor (GHSR), expressed in hypothalamic neurons in the arcuate (ARC). We have shown 17β-estradiol (E2) increases Ghsr expression… read more here.
Keywords: ghsr; ghrelin; growth hormone; secretagogue receptor ... See more keywords