GHSR1a deficiency suppresses inhibitory drive on dCA1 pyramidal neurons and contributes to memory reinforcement.
Sign Up to like & getrecommendations! Published in 2022 at "Cerebral cortex"
DOI: 10.1093/cercor/bhac230
Abstract: Growth hormone secretagogue receptor 1a (GHSR1a)-the receptor for orexigenic hormone ghrelin-is a G protein-coupled receptor that is widely distributed in the brain, including the hippocampus. Studies have demonstrated that genetic deletion of GHSR1a affects memory,… read more here.
Keywords: pyramidal neurons; ghsr1a; ghsr1a deficiency; memory ... See more keywords
The GPCR accessory protein MRAP2 regulates both biased signaling and constitutive activity of the ghrelin receptor GHSR1a
Sign Up to like & getrecommendations! Published in 2020 at "Science Signaling"
DOI: 10.1126/scisignal.aax4569
Abstract: An accessory protein suppresses β-arrestin–dependent signaling and constitutive activity of the ghrelin receptor. Skewing signaling with an accessory protein Ghrelin is a peptide that is secreted by the stomach during fasting to promote food intake.… read more here.
Keywords: protein; accessory protein; constitutive activity; ghsr1a ... See more keywords
Changes in the Cardiac GHSR1a-Ghrelin System Correlate With Myocardial Dysfunction in Diabetic Cardiomyopathy in Mice
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DOI: 10.1210/js.2017-00433
Abstract: Ghrelin and its receptor, the growth hormone secretagogue receptor 1a (GHSR1a), are present in cardiac tissue. Activation of GHSR1a by ghrelin promotes cardiomyocyte contractility and survival, and changes in myocardial GHSR1a and circulating ghrelin track… read more here.
Keywords: group; ghsr1a ghrelin; diabetic cardiomyopathy; ghsr1a ... See more keywords
Establishment of a Cell Line Stably Expressing the Growth Hormone Secretagogue Receptor to Identify Crocin as a Ghrelin Agonist
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12121813
Abstract: The growth hormone secretagogue receptor-1a (GHSR1a) is the endogenous receptor for ghrelin. Activation of GHSR1a participates in many physiological processes including energy homeostasis and eating behavior. Due to its transitory half-life, the efficacy of ghrelin… read more here.
Keywords: ghsr1a; cell; growth hormone; secretagogue receptor ... See more keywords