Peripheral blood GILZ mRNA levels in depression and following electroconvulsive therapy
Sign Up to like & getrecommendations! Published in 2019 at "Psychoneuroendocrinology"
DOI: 10.1016/j.psyneuen.2018.12.234
Abstract: Dysregulation of the hypothalamic-pituitary-adrenocortical (HPA)-axis is commonly observed in patients with depression. The delayed feedback system that mediates inhibition of HPA-axis activation is regulated by glucocorticoid receptors (GRs) found in stress-responsive areas of the brain.… read more here.
Keywords: depression; gilz mrna; mrna levels; gilz ... See more keywords
FRI0268 Glucocorticoid-induced leucine zipper (GILZ) represents a checkpoint limiting type i interferon (IFN) production in sle
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.1847
Abstract: Background Glucocorticoids (GC) remain the mainstay of treatment in Systemic Lupus Erythematosus (SLE). Type I interferons (IFN), produced by plasmacytoid dendritic cells (pDC) in response to Toll-Like receptors (TLR) ligands, are critical to SLE pathogenesis,… read more here.
Keywords: sle; ifn production; gilz; response ... See more keywords
FRI0269 Deficiency of glucocorticoid-induced leucine zipper (GILZ) disinhibits ifn pathways and exacerbates nephritis in the lyn-deficient murine model of lupus
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.4094
Abstract: Background Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease of unknown etiology. Lyn-deficient mice develop lupus-like autoimmunity due to hyperactive B cells resulting in excess IL-6 production, and cyclical exacerbation of inflammation by further… read more here.
Keywords: lyn deficient; glucocorticoid induced; gilz; mice ... See more keywords
Role of glucocorticoid-induced leucine zipper (GILZ) in inflammatory bone loss
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0181133
Abstract: TNF-α plays a key role in the development of rheumatoid arthritis (RA) and inflammatory bone loss. Unfortunately, treatment of RA with anti-inflammatory glucocorticoids (GCs) also causes bone loss resulting in osteoporosis. Our previous studies showed… read more here.
Keywords: inflammatory bone; tnf; bone; gilz ... See more keywords
Non-canonical Glucocorticoid Receptor Transactivation of gilz by Alcohol Suppresses Cell Inflammatory Response
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2017.00661
Abstract: Acute alcohol exposure suppresses cell inflammatory response. The underlying mechanism has not been fully defined. Here we report that alcohol was able to activate glucocorticoid receptor (GR) signaling in the absence of glucocorticoids (GCs) and… read more here.
Keywords: cell inflammatory; inflammatory response; non canonical; gilz ... See more keywords
Implicating the Role of GILZ in Glucocorticoid Modulation of T-Cell Activation
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.01823
Abstract: Glucocorticoid-induced leucine zipper (GILZ) is a protein with multiple biological roles that is upregulated by glucocorticoids (GCs) in both immune and non-immune cells. Importantly, GCs are immunosuppressive primarily due to their regulation of cell signaling… read more here.
Keywords: gcs cells; cell activation; gilz; cell ... See more keywords
Glucocorticoid-Induced Leucine Zipper: A Promising Marker for Monitoring and Treating Sepsis
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.606649
Abstract: Sepsis is a clinical syndrome that resulting from a dysregulated inflammatory response to infection that leads to organ dysfunction. The dysregulated inflammatory response transitions from a hyper-inflammatory phase to a hypo-inflammatory or immunosuppressive phase. Currently,… read more here.
Keywords: sepsis; leucine zipper; glucocorticoid induced; gilz ... See more keywords
GILZ Regulates the Expression of Pro-Inflammatory Cytokines and Protects Against End-Organ Damage in a Model of Lupus
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.652800
Abstract: Glucocorticoid-induced leucine zipper (GILZ) mimics many of the anti-inflammatory effects of glucocorticoids, suggesting it as a point of therapeutic intervention that could bypass GC adverse effects. We previously reported that GILZ down-regulation is a feature… read more here.
Keywords: regulates expression; gilz regulates; gilz; lupus ... See more keywords
Glucocorticoid-Induced Leucine Zipper: A Novel Anti-inflammatory Molecule
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2019.00308
Abstract: Glucocorticoids (GCs) are the most commonly used drugs for treatment of autoimmune and inflammatory diseases. Their efficacy is due to their ability to bind cytoplasmic receptors (glucocorticoid receptors, GR) and other cytoplasmic proteins, thus regulating… read more here.
Keywords: anti inflammatory; leucine zipper; glucocorticoid induced; gilz ... See more keywords
Association of GILZ with MUC2, TLR2, and TLR4 in Inflammatory Bowel Disease
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032235
Abstract: Ulcerative colitis (UC) and Crohn’s Disease (CD) are chronic relapsing inflammatory diseases that are caused by genetic, environmental, and immune factors. Treatment strategies are currently based on symptomatic control by immunosuppression. The glucocorticoid-induced leucine zipper… read more here.
Keywords: disease; inflammatory bowel; gilz; gilz muc2 ... See more keywords
SOCS3 Attenuates Dexamethasone-Induced M2 Polarization by Down-Regulation of GILZ via ROS- and p38 MAPK-Dependent Pathways
Sign Up to like & getrecommendations! Published in 2022 at "Immune Network"
DOI: 10.4110/in.2022.22.e33
Abstract: Suppressors of cytokine signaling (SOCS) have emerged as potential regulators of macrophage function. We have investigated mechanisms of SOCS3 action on type 2 macrophage (M2) differentiation induced by glucocorticoid using human monocytic cell lines and… read more here.
Keywords: ros p38; gilz; p38 mapk; regulation ... See more keywords