[6]‐Gingerol–induced cell cycle arrest, reactive oxygen species generation, and disruption of mitochondrial membrane potential are associated with apoptosis in human gastric cancer (AGS) cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22206
Abstract: Ginger (Zingiber officinale Roscoe), a monocotyledonous herb, is widely used as an herbal medicine owing to the phytoconstituents it possesses. In the current study, the quantity of [6]‐gingerol, the major phenolic ketone, in the fresh… read more here.
Keywords: reactive oxygen; oxygen species; gingerol; human gastric ... See more keywords
Elucidating the Role of Protandim and 6‐Gingerol in Protection Against Osteoarthritis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25659
Abstract: Protandim and 6‐gingerol, two potent nutraceuticals, have been shown to decrease free radicals production through enhancing endogenous antioxidant enzymes. In this study, we evaluated the effects of these products on the expression of different factors… read more here.
Keywords: elucidating role; protection; gingerol; protandim gingerol ... See more keywords
[6]‐Gingerol enhances the cisplatin sensitivity of gastric cancer cells through inhibition of proliferation and invasion via PI3K/AKT signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Phytotherapy Research"
DOI: 10.1002/ptr.6325
Abstract: Cisplatin‐based chemotherapy is a widely used chemotherapeutic regimen for gastric cancer; however, drug resistance limits its efficacy. [6]‐Gingerol has been found to exhibit anticancer effects. Here, we aim to explore the potential of [6]‐gingerol in… read more here.
Keywords: invasion; gingerol; gastric cancer; pi3k akt ... See more keywords
Heat sensitization of hepatitis A virus and Tulane virus using grape seed extract, gingerol and curcumin.
Sign Up to like & getrecommendations! Published in 2020 at "Food microbiology"
DOI: 10.1016/j.fm.2020.103461
Abstract: Human noroviruses (HNoV) and hepatitis A virus (HAV) are predominantly linked to foodborne outbreaks worldwide. As cell-culture systems to propagate HNoV in laboratories are not easily available, Tulane virus (TV) is used as a cultivable… read more here.
Keywords: seed; gingerol; hepatitis virus; min ... See more keywords
The interaction between bovine serum albumin and [6]-,[8]- and [10]-gingerol: an effective strategy to improve the solubility and stability of gingerol
Sign Up to like & getrecommendations! Published in 2021 at "Food Chemistry"
DOI: 10.1016/j.foodchem.2021.131280
Abstract: Abstract In this study, the binding mechanism between bovine serum albumin (BSA) and three gingerols ([6]-, [8]- and [10]-gingerol) was evaluated to explore an effective strategy for improving solubility and stability of gingerols. The fluorescence… read more here.
Keywords: bsa; gingerol; solubility; interaction ... See more keywords
[6]-Gingerol exhibits potent anti-mycobacterial and immunomodulatory activity against tuberculosis.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106809
Abstract: The currently available anti-tuberculosis treatment (ATT) comprises exclusively of anti-bacterial drugs, is very lengthy, has adverse side effects on the host and leads to the generation of drug-resistant variants. Therefore, a combination therapy directed against… read more here.
Keywords: anti mycobacterial; gingerol; drug; tuberculosis ... See more keywords
Cytochrome P450 metabolism studies of [6]-gingerol, [8]-gingerol, and [10]-gingerol by liver microsomes of humans and different species combined with expressed CYP enzymes
Sign Up to like & getrecommendations! Published in 2023 at "RSC Advances"
DOI: 10.1039/d2ra06184h
Abstract: Gingerols, mainly [6]-gingerol (6G), [8]-gingerol (8G), and [10]-gingerol (10G), are the functional and specific pungent phytochemicals in ginger. However, poor oral bioavailability limits their applications owing to extensive metabolism. The present study aims to characterize… read more here.
Keywords: metabolism; gingerol gingerol; liver microsomes; cyp enzymes ... See more keywords
6-Gingerol Alleviates Ferroptosis and Inflammation of Diabetic Cardiomyopathy via the Nrf2/HO-1 Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/3027514
Abstract: Background Diabetes mellitus (DM) can induce cardiomyocyte injury and lead to diabetic cardiomyopathy (DCM) which presently has no specific treatments and consequently increase risk of mortality. Objective To characterize the therapeutic effect of 6-gingerol (6-G)… read more here.
Keywords: inflammation; nrf2 pathway; ferroptosis inflammation; gingerol ... See more keywords
6-Gingerol, a functional polyphenol of ginger, reduces pulmonary fibrosis by activating Sirtuin1.
Sign Up to like & getrecommendations! Published in 2022 at "Allergologia et immunopathologia"
DOI: 10.15586/aei.v50i2.533
Abstract: Pulmonary fibrosis in general is the final common outcome of various interstitial lung diseases. In recent years, the incidence of pulmonary fibrosis has been rising with poor prognosis. 6-gingerol is deemed as a functional polyphenol… read more here.
Keywords: functional polyphenol; polyphenol ginger; pulmonary fibrosis; lung ... See more keywords
6-Gingerol inhibits hair cycle via induction of MMP2 and MMP9 expression.
Sign Up to like & getrecommendations! Published in 2017 at "Anais da Academia Brasileira de Ciencias"
DOI: 10.1590/0001-3765201720170354
Abstract: 6-Gingerol is the major active constituent of ginger. In the current study, we aimed to investigate the mechanisms underlying the effects of 6-Gingerol on hair growth. Mice were randomly divided into five groups; after hair… read more here.
Keywords: hair; gingerol; expression; mmp2 mmp9 ... See more keywords
[10]-gingerol induces apoptosis and inhibits metastatic dissemination of triple negative breast cancer in vivo
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.20139
Abstract: There is increasing interest in the use of non-toxic natural products for the treatment of various pathologies, including cancer. In particular, biologically active constituents of the ginger oleoresin (Zingiber officinale Roscoe) have been shown to… read more here.
Keywords: vivo; gingerol; breast cancer; cancer ... See more keywords