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   Articles with "gingipain" as a keyword



Gingipain regulates isoform switches of PD-L1 in macrophages infected with Porphyromonas gingivalis

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-94954-7

Abstract: Periodontal pathogen Porphyromonas gingivalis (P. gingivalis) is believed to possess immune evasion capabilities, but it remains unclear whether this immune evasion is related to host gene alternative splicing (AS). In this study, RNA-sequencing revealed significant… read more here.

Keywords: gingipain; gingipain regulates; regulates isoform; gingivalis ... See more keywords

Porphyromonas gingivalis laboratory strains and clinical isolates exhibit different distribution of cell surface and secreted gingipains

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recommendations! Published in 2020 at "Journal of Oral Microbiology"

DOI: 10.1080/20002297.2020.1858001

Abstract: ABSTRACT Background: The cell-surface cysteine proteinases RgpA, RgpB (Arg-gingipain), and Kgp (Lys-gingipain) are major virulence factors of P. gingivalis, a keystone pathogen in the development of destructive periodontal disease. The gingipains function as proteinases and… read more here.

Keywords: cell surface; lys gingipain; clinical isolates; gingipain ... See more keywords

Lys-specific gingipain (Kgp) of P. gingivalis promotes viral infection by disabling the interferon pathway

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recommendations! Published in 2025 at "mBio"

DOI: 10.1128/mbio.00298-25

Abstract: ABSTRACT Periodontitis (PD) is a chronic inflammatory disease of the periodontium with a high prevalence and is considered a potential risk factor for the development of other diseases. These include viral infections of the upper… read more here.

Keywords: gingipain; virus; infection; gingivalis ... See more keywords

Inhibitory activity of mangiferin against Porphyromonas gingivalis gingipain K, a causal agent of Alzheimer?s disease: An integrated in vitro and in silico study

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recommendations! Published in 2024 at "ScienceAsia"

DOI: 10.2306/scienceasia1513-1874.2024.073

Abstract: : Gingipain K, a virulence protein from Porphyromonas gingivalis , is involved in the pathogenesis of Alzheimer’s disease. Hence, this research aimed to investigate the potential of methanolic extract of Cratoxylum cochinchinese leaves (CME) and… read more here.

Keywords: mangiferin; gingipain; alzheimer disease; activity ... See more keywords