Porphyromonas gingivalis infection of oral keratinocytes drives the release of pro-inflammatory extracellular vesicles
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DOI: 10.1038/s41598-025-10078-y
Abstract: Periodontitis is an inflammatory disease caused by bacterial infection. Recent studies have identified extracellular vesicles (EVs) as potential mediators of inflammation. This study aimed to evaluate the pro-inflammatory properties and miRNA content of EVs secreted… read more here.
Keywords: gingivalis infection; pro inflammatory; ecs evs; inflammatory ... See more keywords
Porphyromonas gingivalis Infection Upregulates the Endothelin (ET) System in Brain Microvascular Endothelial Cells.
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DOI: 10.1139/cjpp-2022-0035
Abstract: Endothelin-1 (ET-1), the most potent vasoconstrictor identified to date, contributes to cerebrovascular dysfunction and brain ET-1 levels were shown to be related to ADRD progression. ET-1 also contributes to neuroinflammation, especially in infections of the… read more here.
Keywords: system; brain microvascular; infection; porphyromonas gingivalis ... See more keywords
P. gingivalis Infection Upregulates PD-L1 Expression on Dendritic Cells, Suppresses CD8+ T-cell Responses, and Aggravates Oral Cancer
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DOI: 10.1158/2326-6066.cir-22-0541
Abstract: Immunosuppressive properties of the oral anaerobic bacterium Porphyromonas gingivalis are revealed, highlighting effects of the bacterium that facilitate oral cancer progression. The data suggest that P. gingivalis, and/or signaling it mediates, can be targeted to… read more here.
Keywords: upregulates expression; infection upregulates; oral cancer; gingivalis ... See more keywords
Abstract Fri045: Hepatic microbiome changes induced by atherogenic Porphyromonas gingivalis infection
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DOI: 10.1161/res.137.suppl_1.fri045
Abstract: The microbiome, an ecosystem of microorganisms throughout the human body, interact and influence the host’s immune system, potentially affecting disease progression or remission. There have been many clinical studies revealing higher prevalence of atherosclerosis in… read more here.
Keywords: gingivalis infection; infection; gingivalis; hepatic microbiome ... See more keywords