Hypomorphic GINS3 variants alter DNA replication and cause Meier-Gorlin syndrome
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DOI: 10.1172/jci.insight.155648
Abstract: The eukaryotic CDC45/MCM2-7/GINS (CMG) helicase unwinds the DNA double helix during DNA replication. The GINS subcomplex is required for helicase activity and is, therefore, essential for DNA replication and cell viability. Here, we report the… read more here.
Keywords: replication; gins3; meier gorlin; gorlin syndrome ... See more keywords
A novel prognostic biomarker: GINS3 is correlated with methylation and immune escape in liver hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Translational Cancer Research"
DOI: 10.21037/tcr-22-2565
Abstract: Background Liver cancer remains one of the tricky malignancies nowadays. GINS complex subunit 3 (GINS3), part of the GINS tetrameric complex, is significantly upregulated in many cancers, including liver hepatocellular carcinoma (LIHC). With the development… read more here.
Keywords: biomarker; gins3; liver hepatocellular; immune ... See more keywords