Ginsenoside Rg3 attenuates cisplatin-induced kidney injury through inhibition of apoptosis and autophagy-inhibited NLRP3.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.22896
Abstract: The NOD-like receptor family pyrin domain-containing (NLRP3) inflammasomes is centrally implicated in cisplatin (CP)-induced kidney injury. Autophagy is critical for inhibiting production of NLRP3 protein that effectively reduces the inflammatory response. Ginsenoside Rg3 (SY), an… read more here.
Keywords: kidney injury; induced kidney; inhibition; cisplatin induced ... See more keywords
Cloning, overexpression and characterization of a thermostable β-xylosidase from Thermotoga petrophila and cooperated transformation of ginsenoside extract to ginsenoside 20(S)-Rg3 with a β-glucosidase.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.12.026
Abstract: A thermostable β-xylosidase gene Tpexyl3 from Thermotoga petrophila DSM 13,995 was cloned and overexpressed by Escherichia coli. Recombinant Tpexyl3 was purified, and its molecular weight was approximately 86.7 kDa. Its optimal activity was exhibited at pH… read more here.
Keywords: ginsenoside; thermotoga petrophila; ginsenoside extract; rg3 ... See more keywords
20(R)‐ginsenoside Rg3, a rare saponin from red ginseng, ameliorates acetaminophen‐induced hepatotoxicity by suppressing PI3K/AKT pathway‐mediated inflammation and apoptosis
Sign Up to like & getrecommendations! Published in 2018 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2018.03.030
Abstract: ABSTRACT Although ginsenoside Rg3 was isolated as a major component of Korea red ginseng and confirmed to exert potential hepatoprotective effect on acetaminophen (APAP)‐induced liver injury via induction of glutathione S‐transferase (GST) in vitro, thein… read more here.
Keywords: apoptosis; pi3k akt; rg3; apap induced ... See more keywords
Ginsenoside Rg3 improves cyclophosphamide-induced immunocompetence in Balb/c mice.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.04.003
Abstract: Ginsenoside Rg3 (Rg3), which comprises Panax ginseng, is commonly used to improve the immunocompetence of cancer patients undergoing chemotherapy. This study was designed to elucidate the immunoenhancement effects of Rg3 in immunosuppressed mice induced by… read more here.
Keywords: rg3; immunocompetence; mice; balb mice ... See more keywords
Ginsenoside Rg3-enriched red ginseng extract inhibits platelet activation and in vivo thrombus formation
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Ginseng Research"
DOI: 10.1016/j.jgr.2016.11.003
Abstract: Background Korean Red Ginseng has been used for several decades to treat many diseases, enhancing both immunity and physical strength. Previous studies have documented the therapeutic effects of ginseng, including its anticancer, antiaging, and anti-inflammatory… read more here.
Keywords: rg3 rge; ginseng; red ginseng; ginsenoside rg3 ... See more keywords
A new role for the ginsenoside RG3 in antiaging via mitochondria function in ultraviolet-irradiated human dermal fibroblasts☆
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Ginseng Research"
DOI: 10.1016/j.jgr.2018.07.003
Abstract: Background The efficacy of ginseng, the representative product of Korea, and its chemical effects have been well investigated. The ginsenoside RG3 has been reported to exhibit apoptotic, anticancer, and antidepressant-like effects. Methods In this report,… read more here.
Keywords: human dermal; ultraviolet irradiated; rg3; function ... See more keywords
Differential antiangiogenic and anticancer activities of the active metabolites of ginsenoside Rg3
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Ginseng Research"
DOI: 10.1016/j.jgr.2021.05.008
Abstract: Abstract Background Epimers of ginsenoside Rg3 (Rg3) have a low bioavailability and are prone to deglycosylation, which produces epimers of ginsenoside Rh2 (S-Rh2 and R-Rh2) and protopanaxadiol (S-PPD and R-PPD). The aim of this study… read more here.
Keywords: studied using; rh2; ppd; cell ... See more keywords
Ginsenoside Rg3 inhibits grass carp reovirus replication in grass carp ovarian epithelial cells.
Sign Up to like & getrecommendations! Published in 2020 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2020.104174
Abstract: Ginseng exhibits multiple medicinal properties, including the improvement of immune function and enhancing disease resistance. In this study, we investigated the inhibitory effects of ginsenoside Rg3 on grass carp reovirus (GCRV) infection of grass carp… read more here.
Keywords: carp reovirus; ginsenoside rg3; grass carp;
The effect of ginsenoside Rg3 combined with chemotherapy on immune function in non-small cell lung cancer: A systematic review and meta-analysis of randomized controlled trials
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000033463
Abstract: Background: The occurrence and development of non-small cell lung cancer (NSCLC) are closely related to the immune status of the tumor-host. The immunosuppression caused by tumor cells and toxic side effects produced by chemotherapeutic drugs… read more here.
Keywords: ginsenoside rg3; immune function; chemotherapy; cell ... See more keywords
Engineering of triterpene metabolism and overexpression of the lignin biosynthesis gene PAL promotes ginsenoside Rg3 accumulation in ginseng plant chassis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of integrative plant biology"
DOI: 10.1111/jipb.13315
Abstract: The ginsenoside Rg3 found in Panax species has extensive pharmacological properties, in particular anti-cancer effects. However, its natural yield in Panax plants is limited. Here, we report a multi-modular strategy to improve yields of Rg3… read more here.
Keywords: ginsenoside rg3; biosynthesis; ginsenoside; overexpression ... See more keywords
Ginsenoside Rg3 inhibits angiogenesis in a rat model of endometriosis through the VEGFR-2-mediated PI3K/Akt/mTOR signaling pathway
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0186520
Abstract: Objective This study aimed to investigate the link between the inhibitory effect of ginsenoside Rg3 on the ectopic endometrium growth and the VEGFR-2-mediated PI3K/Akt/mTOR signaling pathway, a mechanism known to inhibit angiogenesis and induce ectopic… read more here.
Keywords: ginsenoside rg3; akt mtor; group;