The pathogenic role of the GIP/GIPR axis in human endocrine tumors: emerging clinical mechanisms beyond diabetes
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DOI: 10.1007/s11154-019-09536-6
Abstract: The glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone produced in the gastrointestinal tract in response to nutrients. GIP has a variety of effects on different systems, including the potentiation of insulin secretion from pancreatic… read more here.
Keywords: gipr axis; gipr; endocrine tumors; gip gipr ... See more keywords
Canagliflozin Increases Postprandial Total Glucagon-Like Peptide 1 Levels in the Absence of α-Glucosidase Inhibitor Therapy in Patients with Type 2 Diabetes: A Single-Arm, Non-randomized, Open-Label Study
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DOI: 10.1007/s13300-019-00689-w
Abstract: To investigate canagliflozin-induced changes in postprandial total glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) levels in patients with type 2 diabetes mellitus (T2DM). Forty-five patients with T2DM who had inadequate glycemic control (glycated… read more here.
Keywords: postprandial total; glp; gip; glucosidase inhibitor ... See more keywords
The Role of Tirzepatide, Dual GIP and GLP-1 Receptor Agonist, in the Management of Type 2 Diabetes: The SURPASS Clinical Trials
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DOI: 10.1007/s13300-020-00981-0
Abstract: Glucagon-like peptide 1 (GLP-1) based therapy is an established treatment option for the management of type 2 diabetes mellitus (T2DM) and is recommended early in the treatment algorithm owing to glycaemic efficacy, weight reduction and favourable cardiovascular… read more here.
Keywords: glp; gip; clinical trials; glp receptor ... See more keywords
Inhibition of GIP signaling extends lifespan without caloric restriction.
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DOI: 10.1016/j.bbrc.2019.04.036
Abstract: AIMS/INTRODUCTION Caloric restriction (CR) promotes longevity and exerts anti-aging effects by increasing Sirtuin production and activation. Gastric inhibitory polypeptide (GIP), a gastrointestinal peptide hormone, exerts various effects on pancreatic β-cells and extra-pancreatic tissues. GIP promotes… read more here.
Keywords: inhibition gip; caloric restriction; gip signaling; gip ... See more keywords
Subcutaneous GIP and GLP-2 inhibit nightly bone resorption in postmenopausal women: a preliminary study.
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DOI: 10.1016/j.bone.2021.116065
Abstract: BACKGROUND Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-2 (GLP-2) are gut hormones secreted in response to food ingestion, and they have been suggested to regulate bone turnover. In humans, exogenous GIP and GLP-2 acutely inhibit… read more here.
Keywords: gip glp; gip; bone resorption;
An oral GLP-1 and GIP dual receptor agonist improves metabolic disorders in high fat-fed mice.
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DOI: 10.1016/j.ejphar.2021.174635
Abstract: Dual activation of the glucagon-like peptide 1 (GLP-1) receptor and the glucose-dependent insulinotropic polypeptide (GIP) receptor has potential as a novel strategy for treatment of diabesity. Here, we created a hybrid peptide which we named… read more here.
Keywords: oral glp; fat fed; gip; high fat ... See more keywords
Different mechanisms of GIP and GLP-1 action explain their different therapeutic efficacy in type 2 diabetes.
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DOI: 10.1016/j.metabol.2020.154415
Abstract: BACKGROUND AND AIMS The reduced action of incretin hormones in type 2 diabetes (T2D) is mainly attributed to GIP insensitivity, but efficacy estimates of GIP and GLP-1 differ among studies, and the negligible effects of… read more here.
Keywords: t2d; type diabetes; gip; gip glp ... See more keywords
Molecular evolution of GIP and Exendin and their receptors
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DOI: 10.1016/j.peptides.2019.170158
Abstract: Glucose-dependent insulinotropic polypeptide (GIP) is a product of the Gip gene and acts as an incretin hormone in mammals. Gip is most closely related to the proglucagon (Gcg) and Exendin genes and diverged from these… read more here.
Keywords: evolution; gip exendin; exendin; gip ... See more keywords
GIP’s involvement in the pathophysiology of type 2 diabetes
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DOI: 10.1016/j.peptides.2019.170178
Abstract: During the past four decades derangements in glucose-dependent insulinotropic polypeptide (GIP) biology has been viewed upon as contributing factors to various parts of the pathophysiology type 2 diabetes. This overview outlines and discusses the impaired… read more here.
Keywords: pathophysiology type; type diabetes; gip; type ... See more keywords
Effects on pancreatic Beta and other Islet cells of the glucose-dependent insulinotropic polypeptide
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DOI: 10.1016/j.peptides.2019.170201
Abstract: Glucose-dependent insulinotropic polypeptide (GIP) is a gut-derived incretin that, in common with glucagon-like peptide-1 (GLP-1), has both insulin releasing and extra-pancreatic glucoregulatory actions. GIP is released in response to glucose or fat absorption and acts… read more here.
Keywords: insulinotropic polypeptide; islet; beta; gip ... See more keywords
The role of GIP in α-cells and glucagon secretion
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DOI: 10.1016/j.peptides.2019.170213
Abstract: Glucose-dependent insulinotropic polypeptide (GIP) is an intestinally derived peptide that is secreted in response to feeding. The GIP receptor (GIPR) is expressed in many cell types involved in the regulation of metabolism, including α- and… read more here.
Keywords: glucagon secretion; gipr activity; secretion; gip ... See more keywords