The pathogenic role of the GIP/GIPR axis in human endocrine tumors: emerging clinical mechanisms beyond diabetes
Sign Up to like & getrecommendations! Published in 2020 at "Reviews in Endocrine and Metabolic Disorders"
DOI: 10.1007/s11154-019-09536-6
Abstract: The glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone produced in the gastrointestinal tract in response to nutrients. GIP has a variety of effects on different systems, including the potentiation of insulin secretion from pancreatic… read more here.
Keywords: gipr axis; gipr; endocrine tumors; gip gipr ... See more keywords
The activation of GIP/GIPR axis via Sonic hedgehog signaling promotes the bridging of gapped nerves in sciatic nerve injury.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of neurochemistry"
DOI: 10.1111/jnc.15816
Abstract: Schwann cells play an essential role in peripheral nerve regeneration by generating a favorable microenvironment. Gastric inhibitory peptide/ gastric inhibitory peptide receptor (GIP/GIPR) axis deficiency leads to failure of sciatic nerve repair. However, the underlying… read more here.
Keywords: sciatic nerve; schwann; gip gipr; gipr ... See more keywords
The GIP/GIPR axis in medullary thyroid cancer: clinical and molecular findings.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrine-related cancer"
DOI: 10.1530/erc-21-0258
Abstract: The improper expression of glucose-dependent insulinotropic polypeptide receptor (GIPR) and the GIP/GIPR axis activation has been increasingly recognized in endocrine tumors, with a potential diagnostic and prognostic value. A high tumor-to-normal tissue ratio (T/N ratio)… read more here.
Keywords: mtc; gipr axis; gip gipr; gipr ... See more keywords