GLP1-GIP receptor co-agonists: a promising evolution in the treatment of type 2 diabetes
Sign Up to like & getrecommendations! Published in 2024 at "Acta Diabetologica"
DOI: 10.1007/s00592-024-02300-6
Abstract: Type 2 diabetes represents a growing challenge for global public health. Its prevalence is increasing worldwide, and, like obesity, it affects progressively younger populations compared to the past, with potentially greater impact on chronic complications.… read more here.
Keywords: gip receptor; receptor agonists; type; type diabetes ... See more keywords
Physiological roles of the GIP receptor in murine brown adipose tissue
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2019.08.006
Abstract: Objective Glucose-dependent insulinotropic polypeptide (GIP) is secreted from the gut in response to nutrient ingestion and promotes meal-dependent insulin secretion and lipid metabolism. Loss or attenuation of GIP receptor (GIPR) action leads to resistance to… read more here.
Keywords: bat; adipose tissue; gip receptor; body ... See more keywords
Spatiotemporal GLP-1 and GIP receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2021.101181
Abstract: Objective We assessed the spatiotemporal GLP-1 and GIP receptor signaling, trafficking, and recycling dynamics of GIPR mono-agonists, GLP-1R mono-agonists including semaglutide, and GLP-1/GIP dual-agonists MAR709 and tirzepatide. Methods Receptor G protein recruitment and internalization/trafficking dynamics… read more here.
Keywords: spatiotemporal glp; glp; glp gip; receptor ... See more keywords
Islet adaptation in GIP receptor knockout mice
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DOI: 10.1016/j.peptides.2019.170152
Abstract: Glucose-dependent insulinotropic polypeptide (GIP) receptor knockout (KO) mice are tools for studying GIP physiology. Previous results have demonstrated that these mice have impaired insulin response to oral glucose. In this study, we examined the insulin… read more here.
Keywords: receptor; intravenous glucose; gip receptor; receptor mice ... See more keywords
Investigational and emerging gastric inhibitory polypeptide (GIP) receptor-based therapies for the treatment of obesity
Sign Up to like & getrecommendations! Published in 2024 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2024.2377319
Abstract: ABSTRACT Introduction One billion people live with obesity. The most promising medications for its treatment are incretin-based therapies, based on enteroendocrine peptides released in response to oral nutrients, specifically glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic… read more here.
Keywords: receptor; gip receptor; based therapies; weight reduction ... See more keywords
Chronic peptide-based GIP receptor inhibition exhibits modest glucose metabolic changes in mice when administered either alone or combined with GLP-1 agonism
Sign Up to like & getrecommendations! Published in 2021 at "PLoS ONE"
DOI: 10.1371/journal.pone.0249239
Abstract: Combinatorial gut hormone therapy is one of the more promising strategies for identifying improved treatments for metabolic disease. Many approaches combine the established benefits of glucagon-like peptide-1 (GLP-1) agonism with one or more additional molecules… read more here.
Keywords: gip receptor; glp agonism; peptide;
A Contemporary Rationale for Agonism of the GIP Receptor in the Treatment of Obesity
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DOI: 10.2337/dbi24-0026
Abstract: In combatting the obesity crisis, leveraging mechanisms that lower body weight is critical. The finding that treatment with tirzepatide, a glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) receptor agonist, produces profound weight loss… read more here.
Keywords: receptor; obesity; gip receptor; treatment obesity ... See more keywords
GIP Receptor Antagonists in the Pharmacotherapy of Obesity: Physiologic, Genetic, and Clinical Rationale
Sign Up to like & getrecommendations! Published in 2025 at "Diabetes"
DOI: 10.2337/dbi24-0027
Abstract: Obesity is a prevalent disease that also contributes to the incidence and severity of many other chronic diseases and health conditions. Treatment approaches include lifestyle intervention, bariatric surgery, and pharmacological approaches, with glucagon-like peptide 1… read more here.
Keywords: receptor antagonism; receptor; physiologic genetic; obesity ... See more keywords