Inhibition of GIP signaling extends lifespan without caloric restriction.
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DOI: 10.1016/j.bbrc.2019.04.036
Abstract: AIMS/INTRODUCTION Caloric restriction (CR) promotes longevity and exerts anti-aging effects by increasing Sirtuin production and activation. Gastric inhibitory polypeptide (GIP), a gastrointestinal peptide hormone, exerts various effects on pancreatic β-cells and extra-pancreatic tissues. GIP promotes… read more here.
Keywords: inhibition gip; caloric restriction; gip signaling; gip ... See more keywords