The pathogenic role of the GIP/GIPR axis in human endocrine tumors: emerging clinical mechanisms beyond diabetes
Sign Up to like & getrecommendations! Published in 2020 at "Reviews in Endocrine and Metabolic Disorders"
DOI: 10.1007/s11154-019-09536-6
Abstract: The glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone produced in the gastrointestinal tract in response to nutrients. GIP has a variety of effects on different systems, including the potentiation of insulin secretion from pancreatic… read more here.
Keywords: gipr axis; gipr; endocrine tumors; gip gipr ... See more keywords
Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2018.12.001
Abstract: Objective Structurally-improved GIP analogs were developed to determine precisely whether GIP receptor (GIPR) agonism or antagonism lowers body weight in obese mice. Methods A series of peptide-based GIP analogs, including structurally diverse agonists and a… read more here.
Keywords: weight lowering; gipr; mice; body weight ... See more keywords
Targeting the GIPR for obesity: To agonize or antagonize? Potential mechanisms
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2020.101139
Abstract: Background Glucose-dependent insulinotropic peptide (GIP) is one of two incretin hormones that communicate nutrient intake with systemic metabolism. Although GIP was the first incretin hormone to be discovered, the understanding of GIP's biology was quickly… read more here.
Keywords: gipr agonism; gipr; targeting gipr; evidence ... See more keywords
Design of novel therapeutics targeting the glucose-dependent insulinotropic polypeptide receptor (GIPR) to aid weight loss
Sign Up to like & getrecommendations! Published in 2023 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2023.2203911
Abstract: ABSTRACT Introduction With obesity rates growing globally, there is a paramount need for new obesity pharmacotherapies to tackle this pandemic. Areas covered This review focuses on the design of therapeutics that target the glucose-dependent insulinotropic… read more here.
Keywords: glucose dependent; insulinotropic polypeptide; dependent insulinotropic; gipr ... See more keywords
The activation of GIP/GIPR axis via Sonic hedgehog signaling promotes the bridging of gapped nerves in sciatic nerve injury.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of neurochemistry"
DOI: 10.1111/jnc.15816
Abstract: Schwann cells play an essential role in peripheral nerve regeneration by generating a favorable microenvironment. Gastric inhibitory peptide/ gastric inhibitory peptide receptor (GIP/GIPR) axis deficiency leads to failure of sciatic nerve repair. However, the underlying… read more here.
Keywords: sciatic nerve; schwann; gip gipr; gipr ... See more keywords
Hypothalamic and brainstem glucose-dependent insulinotropic polypeptide receptor neurons employ distinct mechanisms to affect feeding.
Sign Up to like & getrecommendations! Published in 2023 at "JCI insight"
DOI: 10.1172/jci.insight.164921
Abstract: Central glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) signaling is critical in GIP-based therapeutics' ability to lower body weight, but pathways leveraged by GIPR pharmacology in the brain remain incompletely understood. We explored the role of… read more here.
Keywords: gipr neurons; glucose dependent; pharmacology; insulinotropic polypeptide ... See more keywords
Enhanced Endosomal Signaling and Desensitization of GLP-1R vs GIPR in Pancreatic Beta Cells
Sign Up to like & getrecommendations! Published in 2023 at "Endocrinology"
DOI: 10.1210/endocr/bqad028
Abstract: Abstract The incretin receptors, glucagon-like peptide-1 receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR), are prime therapeutic targets for the treatment of type 2 diabetes (T2D) and obesity. They are expressed in pancreatic beta cells… read more here.
Keywords: beta; pancreatic beta; glp gipr; gipr ... See more keywords
The GIP/GIPR axis in medullary thyroid cancer: clinical and molecular findings.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrine-related cancer"
DOI: 10.1530/erc-21-0258
Abstract: The improper expression of glucose-dependent insulinotropic polypeptide receptor (GIPR) and the GIP/GIPR axis activation has been increasingly recognized in endocrine tumors, with a potential diagnostic and prognostic value. A high tumor-to-normal tissue ratio (T/N ratio)… read more here.
Keywords: mtc; gipr axis; gip gipr; gipr ... See more keywords
The Methylation Analysis of the Glucose-Dependent Insulinotropic Polypeptide Receptor (GIPR) Locus in GH-Secreting Pituitary Adenomas
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24119264
Abstract: The glucose-dependent insulinotropic polypeptide receptor (GIPR) is aberrantly expressed in about one-third of GH-secreting pituitary adenomas (GH-PAs) and has been associated with a paradoxical increase of GH after a glucose load. The reason for such… read more here.
Keywords: methylation; locus; glucose dependent; insulinotropic polypeptide ... See more keywords
Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.68719
Abstract: Glucose-dependent insulinotropic polypeptide (GIP) is a peptide hormone that exerts crucial metabolic functions by binding and activating its cognate receptor, GIPR. As an important therapeutic target, GIPR has been subjected to intensive structural studies without… read more here.
Keywords: dependent insulinotropic; receptor; glucose dependent; gipr ... See more keywords