Targeting the GIPR for obesity: To agonize or antagonize? Potential mechanisms
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DOI: 10.1016/j.molmet.2020.101139
Abstract: Background Glucose-dependent insulinotropic peptide (GIP) is one of two incretin hormones that communicate nutrient intake with systemic metabolism. Although GIP was the first incretin hormone to be discovered, the understanding of GIP's biology was quickly… read more here.
Keywords: gipr agonism; gipr; targeting gipr; evidence ... See more keywords
GIPR Agonism Inhibits PYY-Induced Nausea-Like Behavior
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DOI: 10.2337/db21-0848
Abstract: The induction of nausea and emesis is a major barrier to maximizing the weight loss profile of obesity medications, and therefore, identifying mechanisms that improve tolerability could result in added therapeutic benefit. The development of… read more here.
Keywords: gipr agonism; induced nausea; nausea; pyy induced ... See more keywords