GIRK channel activity in prelimbic pyramidal neurons regulates the extinction of cocaine conditioned place preference in male mice
Sign Up to like & getrecommendations! Published in 2022 at "Addiction Biology"
DOI: 10.1111/adb.13256
Abstract: Drug‐induced neuroadaptations in the prefrontal cortex (PFC) have been implicated in drug‐associated memories that motivate continued drug use. Chronic cocaine exposure increases pyramidal neuron excitability in the prelimbic subregion of the PFC (PL), an adaptation… read more here.
Keywords: pyramidal neurons; channel activity; girk channel; cocaine ... See more keywords
Amyloid-β oligomers trigger sex-dependent inhibition of GIRK channel activity in hippocampal neurons in mice
Sign Up to like & getrecommendations! Published in 2024 at "Science Signaling"
DOI: 10.1126/scisignal.ado4132
Abstract: Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by amyloid plaques and cognitive decline, the latter of which is thought to be driven by soluble oligomeric amyloid-β (oAβ). The dysregulation of G protein–gated inwardly… read more here.
Keywords: channel; mice; channel activity; girk channel ... See more keywords