Identification of a G-Protein-Independent Activator of GIRK Channels.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107770
Abstract: G-protein-gated inwardly rectifying K+ (GIRK) channels are essential effectors of inhibitory neurotransmission in the brain. GIRK channels have been implicated in diseases with abnormal neuronal excitability, including epilepsy and addiction. GIRK channels are tetramers composed… read more here.
Keywords: identification protein; independent activator; protein independent; girk channels ... See more keywords
Structural insights into GIRK2 channel modulation by cholesterol and PIP2
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DOI: 10.1016/j.celrep.2021.109619
Abstract: SUMMARY G-protein-gated inwardly rectifying potassium (GIRK) channels are important for determining neuronal excitability. In addition to G proteins, GIRK channels are potentiated by membrane cholesterol, which is elevated in the brains of people with neurodegenerative… read more here.
Keywords: modulation; structural insights; cholesterol; channel ... See more keywords
Selective Ablation of GIRK Channels in Dopamine Neurons Alters Behavioral Effects of Cocaine in Mice
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DOI: 10.1038/npp.2016.138
Abstract: The increase in dopamine (DA) neurotransmission stimulated by in vivo cocaine exposure is tempered by G protein-dependent inhibitory feedback mechanisms in DA neurons of the ventral tegmental area (VTA). G protein-gated inwardly rectifying K+ (GIRK/Kir3)… read more here.
Keywords: vta; effect; girk channels; cocaine ... See more keywords
GIRK Channels as Candidate Targets for the Treatment of Substance Use Disorders
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10102552
Abstract: Substance use disorders (SUDs) are chronic, lifelong disorders that have serious consequences. Repeated substance use alters brain function. G-protein-activated inwardly rectifying potassium (GIRK) channels are expressed widely in the brain, including the reward system, and… read more here.
Keywords: girk channels; substance use; use; use disorders ... See more keywords