Targeting the WEE1 kinase strengthens the antitumor activity of imatinib via promoting KIT autophagic degradation in gastrointestinal stromal tumors
Sign Up to like & getrecommendations! Published in 2019 at "Gastric Cancer"
DOI: 10.1007/s10120-019-00977-1
Abstract: Background Activating mutation of KIT or PDGFRA is the primary molecular mechanism for gastrointestinal stromal tumors (GISTs). Although imatinib has a revolutionary effect on GIST therapeutics, the benefits are not durable. Increasing reports have demonstrated… read more here.
Keywords: wee1; inhibition; antitumor activity; kit ... See more keywords
Transanal minimally invasive surgery (TAMIS) for anterior rectal GIST
Sign Up to like & getrecommendations! Published in 2019 at "Techniques in Coloproctology"
DOI: 10.1007/s10151-019-01979-y
Abstract: The incidence of gut gastrointestinal stromal tumors (GISTs) is less than 1%, 90% found in the stomach or small intestine, and only 3% are located in the rectum. Treatment of rectal GISTs needs careful planning… read more here.
Keywords: surgery; transanal minimally; minimally invasive; gist ... See more keywords
The True Incidence of Gastric GIST: an Update
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DOI: 10.1007/s11695-018-3235-7
Abstract: Gastrointestinal stromal tumor (GIST) is a rare neoplasm of the alimentary tract with an incidence of around 1 per 100,000 [1]. The most common location is in the stomach where 60% of these tumors occur… read more here.
Keywords: incidence; true incidence; incidence gastric; gist ... See more keywords
Association Between Gastrointestinal Stromal Tumors and Other Malignancies: It Is Only a Matter of Time ? A Case Series and an Overview of Systematic Reviews
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Gastrointestinal Cancer"
DOI: 10.1007/s12029-019-00324-8
Abstract: Little is known about the sporadic coincidence of gastrointestinal stromal tumors (GISTs) with second primary tumors (SPTs). The aim of this study is to clarify if there is a clinicopathologic correlation responsible for the synchronous… read more here.
Keywords: gist patients; gastrointestinal stromal; stromal tumors; systematic reviews ... See more keywords
Primary Adrenal Gastrointestinal Stromal Tumor (GIST): a Rarest Incidentaloma and Diagnostic Challenge
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DOI: 10.1007/s13193-020-01182-8
Abstract: Gastrointestinal stromal tumors (GISTs), although the commonest mesenchymal tumor of the gastrointestinal tract (GIT), are rare, accounting for < 1% of all malignancies of the GIT [1]. It is seen commonly in older adults with… read more here.
Keywords: primary adrenal; adrenal gastrointestinal; gastrointestinal stromal; gist ... See more keywords
Avapritinib: First Approval
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DOI: 10.1007/s40265-020-01275-2
Abstract: Avapritinib (AYVAKIT™) is a potent and selective tyrosine kinase inhibitor of platelet-derived growth factor receptor alpha (PDGFRA) and KIT activation loop mutants. It is being developed by Blueprint Medicines for the treatment of gastrointestinal stromal… read more here.
Keywords: avapritinib; first approval; treatment; avapritinib first ... See more keywords
Insights into ligand stimulation effects on gastro-intestinal stromal tumors signalling.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2016.10.009
Abstract: Mutations in KIT or PDGFRA are responsible for >85% of gastrointestinal stromal tumors. The introduction of imatinib in the GIST therapy scheme revolutionized the patient outcome. Unfortunately, the therapy allows the disease stabilization instead of… read more here.
Keywords: kinase activity; stromal tumors; gist; kit mutants ... See more keywords
Case report of diffusely metastatic rectal GIST
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DOI: 10.1016/j.ijscr.2017.05.033
Abstract: Highlights • Rectal gastrointestinal tumors (GISTs) are rare mesenchymal tumors.• Rectal GISTs are extremely rare and account for approximately 2% of all GIST tumors.• Majority of GISTs have a benign course.• Treatment with imatinib mesylate… read more here.
Keywords: rectal gist; gist; diffusely metastatic; report diffusely ... See more keywords
Small bowel gastrointestinal stromal tumor presenting with gastrointestinal bleeding in patient with type 1 Neurofibromatosis: Management and laparoscopic treatment. Case report and review of the literature.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of surgery case reports"
DOI: 10.1016/j.ijscr.2020.12.095
Abstract: INTRODUCTION AND IMPORTANCE Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the gastrointestinal tract. It may be asymptomatic; nevertheless, gastrointestinal bleeding is the most frequent symptom, due to mucosal erosion. Its poor… read more here.
Keywords: laparoscopic; gastrointestinal bleeding; bleeding; case ... See more keywords
Viruses, Vaccines, and COVID-19: Explaining and Improving Risky Decision-making
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Applied Research in Memory and Cognition"
DOI: 10.1016/j.jarmac.2021.08.004
Abstract: Risky decision-making lies at the center of the COVID-19 pandemic and will determine future viral outbreaks. Therefore, a critical evaluation of major explanations of such decision-making is of acute practical importance. We review the underlying… read more here.
Keywords: vaccines covid; decision; decision making; risky decision ... See more keywords
Cyclin D1 is a mediator of gastrointestinal stromal tumor KIT-independence
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DOI: 10.1038/s41388-019-0894-3
Abstract: Oncogenic KIT or PDGFRA tyrosine kinase mutations are compelling therapeutic targets in most gastrointestinal stromal tumors (GISTs), and the KIT inhibitor, imatinib, is therefore standard of care for patients with metastatic GIST. However, some GISTs… read more here.
Keywords: kit independent; cyclin expression; kit; expression ... See more keywords