Targeting the WEE1 kinase strengthens the antitumor activity of imatinib via promoting KIT autophagic degradation in gastrointestinal stromal tumors
Sign Up to like & getrecommendations! Published in 2019 at "Gastric Cancer"
DOI: 10.1007/s10120-019-00977-1
Abstract: Background Activating mutation of KIT or PDGFRA is the primary molecular mechanism for gastrointestinal stromal tumors (GISTs). Although imatinib has a revolutionary effect on GIST therapeutics, the benefits are not durable. Increasing reports have demonstrated… read more here.
Keywords: wee1; inhibition; antitumor activity; kit ... See more keywords
Transanal minimally invasive surgery (TAMIS) for anterior rectal GIST
Sign Up to like & getrecommendations! Published in 2019 at "Techniques in Coloproctology"
DOI: 10.1007/s10151-019-01979-y
Abstract: The incidence of gut gastrointestinal stromal tumors (GISTs) is less than 1%, 90% found in the stomach or small intestine, and only 3% are located in the rectum. Treatment of rectal GISTs needs careful planning… read more here.
Keywords: surgery; transanal minimally; minimally invasive; gist ... See more keywords
The True Incidence of Gastric GIST: an Update
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DOI: 10.1007/s11695-018-3235-7
Abstract: Gastrointestinal stromal tumor (GIST) is a rare neoplasm of the alimentary tract with an incidence of around 1 per 100,000 [1]. The most common location is in the stomach where 60% of these tumors occur… read more here.
Keywords: incidence; true incidence; incidence gastric; gist ... See more keywords
Association Between Gastrointestinal Stromal Tumors and Other Malignancies: It Is Only a Matter of Time ? A Case Series and an Overview of Systematic Reviews
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Gastrointestinal Cancer"
DOI: 10.1007/s12029-019-00324-8
Abstract: Little is known about the sporadic coincidence of gastrointestinal stromal tumors (GISTs) with second primary tumors (SPTs). The aim of this study is to clarify if there is a clinicopathologic correlation responsible for the synchronous… read more here.
Keywords: gist patients; gastrointestinal stromal; stromal tumors; systematic reviews ... See more keywords
Primary Adrenal Gastrointestinal Stromal Tumor (GIST): a Rarest Incidentaloma and Diagnostic Challenge
Sign Up to like & getrecommendations! Published in 2020 at "Indian Journal of Surgical Oncology"
DOI: 10.1007/s13193-020-01182-8
Abstract: Gastrointestinal stromal tumors (GISTs), although the commonest mesenchymal tumor of the gastrointestinal tract (GIT), are rare, accounting for < 1% of all malignancies of the GIT [1]. It is seen commonly in older adults with… read more here.
Keywords: primary adrenal; adrenal gastrointestinal; gastrointestinal stromal; gist ... See more keywords
Avapritinib: First Approval
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DOI: 10.1007/s40265-020-01275-2
Abstract: Avapritinib (AYVAKIT™) is a potent and selective tyrosine kinase inhibitor of platelet-derived growth factor receptor alpha (PDGFRA) and KIT activation loop mutants. It is being developed by Blueprint Medicines for the treatment of gastrointestinal stromal… read more here.
Keywords: avapritinib; first approval; treatment; avapritinib first ... See more keywords
Insights into ligand stimulation effects on gastro-intestinal stromal tumors signalling.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2016.10.009
Abstract: Mutations in KIT or PDGFRA are responsible for >85% of gastrointestinal stromal tumors. The introduction of imatinib in the GIST therapy scheme revolutionized the patient outcome. Unfortunately, the therapy allows the disease stabilization instead of… read more here.
Keywords: kinase activity; stromal tumors; gist; kit mutants ... See more keywords
Case report of diffusely metastatic rectal GIST
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Surgery Case Reports"
DOI: 10.1016/j.ijscr.2017.05.033
Abstract: Highlights • Rectal gastrointestinal tumors (GISTs) are rare mesenchymal tumors.• Rectal GISTs are extremely rare and account for approximately 2% of all GIST tumors.• Majority of GISTs have a benign course.• Treatment with imatinib mesylate… read more here.
Keywords: rectal gist; gist; diffusely metastatic; report diffusely ... See more keywords
Small bowel gastrointestinal stromal tumor presenting with gastrointestinal bleeding in patient with type 1 Neurofibromatosis: Management and laparoscopic treatment. Case report and review of the literature.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of surgery case reports"
DOI: 10.1016/j.ijscr.2020.12.095
Abstract: INTRODUCTION AND IMPORTANCE Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the gastrointestinal tract. It may be asymptomatic; nevertheless, gastrointestinal bleeding is the most frequent symptom, due to mucosal erosion. Its poor… read more here.
Keywords: laparoscopic; gastrointestinal bleeding; bleeding; case ... See more keywords
Viruses, Vaccines, and COVID-19: Explaining and Improving Risky Decision-making
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Applied Research in Memory and Cognition"
DOI: 10.1016/j.jarmac.2021.08.004
Abstract: Risky decision-making lies at the center of the COVID-19 pandemic and will determine future viral outbreaks. Therefore, a critical evaluation of major explanations of such decision-making is of acute practical importance. We review the underlying… read more here.
Keywords: vaccines covid; decision; decision making; risky decision ... See more keywords
True and false recognition in MINERVA2: Integrating fuzzy-trace theory and computational memory modeling.
Sign Up to like & getrecommendations! Published in 2025 at "Psychological review"
DOI: 10.1037/rev0000541
Abstract: Previous research suggests that the MINERVA2 model can capture basic Deese/Roediger/McDermott (DRM) false recognition findings with either randomized representations or distributional semantic representations. In the current article, we extended this line of research by showing… read more here.
Keywords: gist; trace theory; false recognition; recognition ... See more keywords