Evaluation of T Regulatory Lymphocytes Transcription Factors in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) Patients
Sign Up to like & getrecommendations! Published in 2017 at "Applied Biochemistry and Biotechnology"
DOI: 10.1007/s12010-017-2406-7
Abstract: HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is an aggressive neurological disease. The CD4+CD25+ T cell population plays pivotal roles in the maintenance of immunological tolerance and prevention of such autoimmune diseases. In the current study, proviral… read more here.
Keywords: ham; tsp patients; ham tsp; gitr ... See more keywords
MEDI1873, a potent, stabilized hexameric agonist of human GITR with regulatory T-cell targeting potential
Sign Up to like & getrecommendations! Published in 2017 at "Oncoimmunology"
DOI: 10.1080/2162402x.2017.1280645
Abstract: ABSTRACT Glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) is part of a system of signals involved in controlling T-cell activation. Targeting and agonizing GITR in mice promotes antitumor immunity by enhancing the function of effector… read more here.
Keywords: agonist; gitr; medi1873; potent ... See more keywords
Model‐informed drug development for immuno‐oncology agonistic anti‐GITR antibody GWN323: Dose selection based on MABEL and biologically active dose
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Translational Science"
DOI: 10.1111/cts.13355
Abstract: GWN323, an agonistic human anti‐GITR (glucocorticoid‐induced TNFR‐related protein) IgG1 antibody, was studied clinically as an immuno‐oncology therapeutic agent. A model‐based minimum anticipated biological effect level (MABEL) approach integrating in vitro and in vivo data informed… read more here.
Keywords: oncology; gitr; model; dose selection ... See more keywords
Therapeutic antibody activation of the glucocorticoid-induced TNF receptor by a clustering mechanism
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abm4552
Abstract: GITR is a TNF receptor, and its activation promotes immune responses and drives antitumor activity. The receptor is activated by the GITR ligand (GITRL), which is believed to cluster receptors into a high-order array. Immunotherapeutic… read more here.
Keywords: activation; therapeutic antibody; antibody; tnf receptor ... See more keywords
Characterization of MK-4166, a Clinical Agonistic Antibody That Targets Human GITR and Inhibits the Generation and Suppressive Effects of T Regulatory Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer research"
DOI: 10.1158/0008-5472.can-16-1439
Abstract: GITR is a T-cell costimulatory receptor that enhances cellular and humoral immunity. The agonist anti-mouse GITR antibody DTA-1 has demonstrated efficacy in murine models of cancer primarily by attenuation of Treg-mediated immune suppression, but the… read more here.
Keywords: suppressive effects; antibody; gitr; characterization ... See more keywords
GITR Agonism Enhances Cellular Metabolism to Support CD8+ T-cell Proliferation and Effector Cytokine Production in a Mouse Tumor Model
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DOI: 10.1158/2326-6066.cir-17-0632
Abstract: GITR stimulation treatment enhances CD8+ T-cell metabolism, proliferation, and effector function. Characterization of the mechanism by which GITR agonist antibodies exert these effects provides insight into their future development in combination therapies. GITR is a… read more here.
Keywords: cd8 cell; cd8; metabolism; proliferation ... See more keywords
Soluble glucocorticoid-induced tumor necrosis factor receptor regulates Helios expression in myasthenia gravis
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DOI: 10.1186/s12967-019-1916-1
Abstract: BackgroundHelios is important for functional and phenotype stability of regulatory T cells (Tregs). However, the role of Helios in autoimmune diseases and its regulation remains unclear. This study aimed to investigate the role of Helios+… read more here.
Keywords: helios tregs; glucocorticoid induced; gitr; expression ... See more keywords
In Vitro Treg Immunosuppression Assay of GITR Proteins Could Elucidate the Autoimmune-mediated Mechanism Underlying Type 1 Narcolepsy
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neurosurgery"
DOI: 10.33137/jns.v2i1.34611
Abstract: Abstract: Type 1 narcolepsy is a hypersomnia sleep disorder characterized by excessive daytime sleep and shallow NREM nighttime sleep. Deficiency of hypocretin-1 secreting neurons in the lateral hypothalamus is the primary cause of the disorder… read more here.
Keywords: type narcolepsy; gitr; mediated mechanism; narcolepsy ... See more keywords