Abstract 3826: GITRL-Fc biomarker and mechanism study: GITRL-Fc reduces Treg frequency in tumors and requires effector function for inhibition of tumor growth
Sign Up to like & getrecommendations! Published in 2018 at "Immunology"
DOI: 10.1158/1538-7445.am2018-3826
Abstract: Activation of the co-stimulatory receptor GITR (Glucocorticoid-Induced Tumor Necrosis Factor Receptor) by GITR-Ligand (GITRL) promotes proliferation and activation of effector T cells (T eff) and inhibits suppressive activity of regulatory T cells (Treg). Here, we… read more here.
Keywords: frequency; gitrl; effector function; tumor ... See more keywords
GITRL on dendritic cells aggravates house dust mite-induced airway inflammation and airway hyperresponsiveness by modulating CD4+ T cell differentiation
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DOI: 10.1186/s12931-020-01583-x
Abstract: Background Glucocorticoid-induced tumor necrosis factor receptor family-related protein ligand (GITRL) plays an important role in tumors, autoimmunity and inflammation. However, GITRL is not known to modulate the pathogenesis of allergic asthma. In this study, we… read more here.
Keywords: gitrl; inflammation; cell differentiation; dendritic cells ... See more keywords