Highly Potent 2-Oxoester Inhibitors of Cytosolic Phospholipase A2 (GIVA cPLA2)
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DOI: 10.1021/acsomega.8b01214
Abstract: Cytosolic phospholipase A2 (GIVA cPLA2) has attracted great interest as a medicinal target because it initiates the eicosanoid cascade and is involved in a number of inflammatory diseases. As a consequence, the development of potent… read more here.
Keywords: highly potent; oxoester; cytosolic phospholipase; giva cpla2 ... See more keywords
2-Oxoesters: A Novel Class of Potent and Selective Inhibitors of Cytosolic Group IVA Phospholipase A2
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DOI: 10.1038/s41598-017-07330-5
Abstract: Cytosolic phospholipase A2 (GIVA cPLA2) is the only PLA2 that exhibits a marked preference for hydrolysis of arachidonic acid containing phospholipid substrates releasing free arachidonic acid and lysophospholipids and giving rise to the generation of… read more here.
Keywords: giva cpla2; potent selective; phospholipase; novel class ... See more keywords
2-Oxoester Phospholipase A2 Inhibitors with Enhanced Metabolic Stability
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DOI: 10.3390/biom10030491
Abstract: 2-Oxoesters constitute an important class of potent and selective inhibitors of human cytosolic phospholipase A2 (GIVA cPLA2) combining an aromatic scaffold or a long aliphatic chain with a short aliphatic chain containing a free carboxylic… read more here.
Keywords: oxoester; metabolic stability; phospholipase; stability ... See more keywords