Overexpression of Astrocytes-Specific GJA1-20k Enhances the Viability and Recovery of the Neurons in a Rat Model of Traumatic Brain Injury.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.0c00142
Abstract: Traumatic brain injury (TBI) is a devastating actuality in clinics worldwide. It is estimated that approximately 10 million people among the world suffer from TBI each year, and a considerable number of patients will be… read more here.
Keywords: overexpression; gja1 20k; recovery neurons; viability recovery ... See more keywords
Abstract 864: Mitochondrial Morphology During Stress is Regulated by GJA1-20k Interaction With Actin
Sign Up to like & getrecommendations! Published in 2019 at "Circulation Research"
DOI: 10.1161/res.125.suppl_1.864
Abstract: Connexin (Cx) 43 is encoded by the GJA1 gene and GJA1-20k has been identified as an N-terminal truncation of Cx43 generated endogenously by internal translation. Previously we have found GJA1-20k increases with ischemic stress and… read more here.
Keywords: actin; stress; mitochondrial morphology; gja1 20k ... See more keywords
Stress response protein GJA1-20k promotes mitochondrial biogenesis, metabolic quiescence, and cardioprotection against ischemia/reperfusion injury.
Sign Up to like & getrecommendations! Published in 2018 at "JCI insight"
DOI: 10.1172/jci.insight.121900
Abstract: Connexin 43 (Cx43), a product of the GJA1 gene, is a gap junction protein facilitating intercellular communication between cardiomyocytes. Cx43 protects the heart from ischemic injury by mechanisms that are not well understood. GJA1 mRNA… read more here.
Keywords: protein; mitochondrial biogenesis; heart; gja1 20k ... See more keywords
Internal translation of Gja1 (Connexin43) to produce GJA1-20k: Implications for arrhythmia and ischemic-preconditioning
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.1058954
Abstract: Internal translation is a form of post-translation modification as it produces different proteins from one mRNA molecule by beginning translation at a methionine coding triplet downstream of the first methionine. Internal translation can eliminate domains… read more here.
Keywords: translation; ischemic preconditioning; translation gja1; gja1 20k ... See more keywords
GJA1-20k and Mitochondrial Dynamics
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.867358
Abstract: Connexin 43 (Cx43) is the primary gap junction protein of mammalian heart ventricles and is encoded by the gene Gja1 which has a single coding exon and therefore cannot be spliced. We previously identified that… read more here.
Keywords: cx43; 20k mitochondrial; gja1; mitochondrial dynamics ... See more keywords