Hepatotoxicity and reproductive disruption in male lizards (Eremias argus) exposed to glufosinate-ammonium contaminated soil.
Sign Up to like & getrecommendations! Published in 2019 at "Environmental pollution"
DOI: 10.1016/j.envpol.2018.12.004
Abstract: Glufosinate-ammonium (GLA) is a spectrum herbicide that is widely used in agriculture. The toxic effects of GLA on plants and mammals have been extensively studied; however, little is known about its effects on reptiles. In… read more here.
Keywords: male lizards; gla; eremias argus; glufosinate ammonium ... See more keywords
Glaucocalyxin A suppresses osteoclastogenesis induced by RANKL and osteoporosis induced by ovariectomy by inhibiting the NF-κB and Akt pathways.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2021.114176
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Glaucocalyxin A (GLA), the most abundant active component of the aboveground sections of Rabdosia japonica (Burm. f.) Hara var. glaucocalyx (Maxim.) Hara, possesses various pharmacological activities, such as antioxidant, antithrombosis, anticoagulation, antibacterial, antitumor,… read more here.
Keywords: osteoclast differentiation; induced rankl; gla; bone ... See more keywords
α-galactosidase A deficiency promotes von Willebrand factor secretion in models of Fabry disease.
Sign Up to like & getrecommendations! Published in 2019 at "Kidney international"
DOI: 10.1016/j.kint.2018.08.033
Abstract: Fabry disease results from loss of activity of the lysosomal enzyme α-galactosidase A (GLA), leading to the accumulation of globoseries glycosphingolipids in vascular endothelial cells. Thrombosis and stroke are life-threatening complications of Fabry disease; however,… read more here.
Keywords: secretion; fabry disease; gla; von willebrand ... See more keywords
Effects of dapagliflozin and/or insulin glargine on beta cell mass and hepatic steatosis in db/db mice.
Sign Up to like & getrecommendations! Published in 2019 at "Metabolism: clinical and experimental"
DOI: 10.1016/j.metabol.2019.06.006
Abstract: OBJECTIVE To explore the beneficial effects of dapagliflozin and/or insulin glargine on the pancreatic beta cell mass and hepatic steatosis in db/db mice. METHODS Six-week-old db/db mice were assigned to one of four groups: untreated… read more here.
Keywords: glargine; cell mass; insulin glargine; gla ... See more keywords
Molecular View into Preferential Binding of the Factor VII Gla Domain to Phosphatidic Acid.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00266
Abstract: Factor VII (FVII) is a serine protease with a key role in initiating the coagulation cascade. It is part of a family of vitamin K-dependent clotting proteins, which require vitamin K for formation of their… read more here.
Keywords: binding; gla domain; factor vii; phosphatidic acid ... See more keywords
Cometary Glycolaldehyde as a Source of Pre-RNA Molecules.
Sign Up to like & getrecommendations! Published in 2020 at "Astrobiology"
DOI: 10.1089/ast.2020.2216
Abstract: Over 200 molecules have been detected in multiple extraterrestrial environments, including glycolaldehyde (C2(H2O)2, GLA), a two-carbon sugar precursor that has been detected in regions of the interstellar medium. Its recent in situ detection on the… read more here.
Keywords: source pre; delivery; gla; glycolaldehyde source ... See more keywords
Deep Autoencoder for Hyperspectral Unmixing via Global-Local Smoothing
Sign Up to like & getrecommendations! Published in 2022 at "IEEE Transactions on Geoscience and Remote Sensing"
DOI: 10.1109/tgrs.2022.3152782
Abstract: Hyperspectral unmixing is to decompose the mixed pixels into pure spectral signatures (endmembers) and their proportions (abundances). Recently, deep learning-based methods have been applied to enhance the representation ability of unmixing models by extracting joint… read more here.
Keywords: gla; hyperspectral unmixing; global local; autoencoder ... See more keywords
Glaucocalyxin A induces apoptosis of non–small cell lung carcinoma cells by inhibiting the PI3K/Akt/GSK3β pathway
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13667
Abstract: Lung cancer is one of the fastest growing malignancies in morbidity and mortality, and current therapies are in general not sufficiently effective for this deadly disease. This study characterizes the anticancer effects of glaucocalyxin A… read more here.
Keywords: cell; pi3k akt; lung; gla ... See more keywords
Chest imaging in generalized lymphatic anomaly and kaposiform lymphangiomatosis
Sign Up to like & getrecommendations! Published in 2018 at "Pediatrics International"
DOI: 10.1111/ped.13593
Abstract: At Gifu University School of Medicine, we identified four cases of generalized lymphatic anomaly (GLA) and three cases of kaposiform lymphangiomatosis (KLA) treated between October 2004 and September 2016. The differentiation of GLA from KLA… read more here.
Keywords: stp; chest; one patient; gla ... See more keywords
Fabry disease due to G171S GLA mutation: An atypical small nerve fiber sparing variant?
Sign Up to like & getrecommendations! Published in 2020 at "European journal of ophthalmology"
DOI: 10.1177/1120672120939496
Abstract: INTRODUCTION To describe the ocular manifestations and in vivo confocal microscopic findings in a patient carrying the recently described hemizygous G171S GLA gene mutation. CASE DESCRIPTION A 63-year-old Albanian male patient was evaluated for cataract… read more here.
Keywords: fabry disease; g171s; disease; gla ... See more keywords
Magnitude of the Potential Screening Gap for Fabry Disease in Manitoba: A Population-Based Retrospective Cohort Study
Sign Up to like & getrecommendations! Published in 2023 at "Canadian Journal of Kidney Health and Disease"
DOI: 10.1177/20543581231162218
Abstract: Background: Fabry disease is a rare disorder caused by the deficient activity of α-galactosidase A (GLA) that often leads to organ damage. Fabry disease can be treated with enzyme replacement or pharmacological therapy, but due… read more here.
Keywords: disease; high risk; gla; fabry disease ... See more keywords