Lyophilization Strategy Enhances the Thermostability and Field-Based Stability of Conjugated and Comixed Subunit Liposomal Adjuvant-containing Tuberculosis Vaccine Formulation (ID93 + GLA-LSQ).
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DOI: 10.1021/acs.molpharmaceut.5c00150
Abstract: ID93 + GLA-LSQ is an adjuvanted recombinant protein vaccine candidate that has demonstrated robust T-cell immunity and reduced bacterial burden in preclinical studies. Here, we explored the strategy of lyophilization by introducing 10% Trehalose as… read more here.
Keywords: formulation; gla; stability; id93 gla ... See more keywords
Interplay of diverse adjuvants and nanoparticle presentation of native-like HIV-1 envelope trimers
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DOI: 10.1038/s41541-021-00364-x
Abstract: The immunogenicity of HIV-1 envelope (Env) trimers is generally poor. We used the clinically relevant ConM SOSIP trimer to compare the ability of different adjuvants (squalene emulsion, ISCOMATRIX, GLA-LSQ, and MPLA liposomes) to support neutralizing… read more here.
Keywords: gla lsq; adjuvants nanoparticle; hiv envelope; presentation ... See more keywords