Activity of Combined Antifungal Agents Against Multidrug-Resistant Candida glabrata Strains
Sign Up to like & getrecommendations! Published in 2017 at "Mycopathologia"
DOI: 10.1007/s11046-017-0141-9
Abstract: In this study, we evaluated the in vitro activity of echinocandins, azoles, and amphotericin B alone and in combination against echinocandin/azole-sensitive and echinocandin/azole-resistant Candida glabrata isolates. Susceptibility tests were performed using the broth microdilution method… read more here.
Keywords: glabrata strains; glabrata; multidrug resistant; resistant candida ... See more keywords
Cooperation between ER stress and calcineurin signaling contributes to the maintenance of cell wall integrity in Candida glabrata.
Sign Up to like & getrecommendations! Published in 2018 at "Fungal biology"
DOI: 10.1016/j.funbio.2017.09.007
Abstract: Candida glabrata is the second most common source of Candida infections in humans. In this pathogen, the maintenance of cell wall integrity (CWI) frequently precludes effective pharmacological treatment by antifungal agents. In numerous fungi, cell… read more here.
Keywords: cell wall; stress; glabrata; candida ... See more keywords
De novo full length transcriptome analysis of Arachis glabrata provides insights into gene expression dynamics in response to biotic and abiotic stresses.
Sign Up to like & getrecommendations! Published in 2021 at "Genomics"
DOI: 10.1016/j.ygeno.2021.03.030
Abstract: The perennial ornamental peanut Arachis glabrata represents one of the most adaptable wild Arachis species. This study used PacBio combined with BGISEQ-500 RNA-seq technology to study the transcriptome and gene expression dynamics of A. glabrata.… read more here.
Keywords: arachis; expression dynamics; glabrata; gene expression ... See more keywords
Transcriptional responses of Candida glabrata biofilm cells to fluconazole are modulated by the carbon source.
Sign Up to like & getrecommendations! Published in 2020 at "NPJ biofilms and microbiomes"
DOI: 10.1038/s41522-020-0114-5
Abstract: Candida glabrata is an important human fungal pathogen known to trigger serious infections in immune-compromised individuals. Its ability to form biofilms, which exhibit high tolerance to antifungal treatments, has been considered as an important virulence… read more here.
Keywords: glabrata biofilm; carbon; glabrata; carbon source ... See more keywords
The CCAAT-Binding Complex Controls Respiratory Gene Expression and Iron Homeostasis in Candida Glabrata
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DOI: 10.1038/s41598-017-03750-5
Abstract: The CCAAT-binding complex (CBC) is a heterotrimeric transcription factor which is widely conserved in eukaryotes. In the model yeast S. cerevisiae, CBC positively controls the expression of respiratory pathway genes. This role involves interactions with… read more here.
Keywords: iron homeostasis; glabrata; expression; iron ... See more keywords
Potential Use of MALDI-ToF Mass Spectrometry for Rapid Detection of Antifungal Resistance in the Human Pathogen Candida glabrata
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-09329-4
Abstract: The echinocandins are relatively new antifungal drugs that represent, together with the older azoles, the recommended and/or preferred agents to treat candidaemia and other forms of invasive candidiasis in human patients. If “time is of… read more here.
Keywords: mass spectrometry; maldi tof; pathogen candida; glabrata ... See more keywords
Glyoxylate cycle gene ICL1 is essential for the metabolic flexibility and virulence of Candida glabrata
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-39117-1
Abstract: The human fungal pathogen Candida glabrata appears to utilise unique stealth, evasion and persistence strategies in subverting the onslaught of host immune response during systemic infection. However, macrophages actively deprive the intracellular fungal pathogen of… read more here.
Keywords: virulence; glyoxylate cycle; glabrata; candida glabrata ... See more keywords
Trk1-mediated potassium uptake contributes to cell-surface properties and virulence of Candida glabrata
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DOI: 10.1038/s41598-019-43912-1
Abstract: The absence of high-affinity potassium uptake in Candida glabrata, the consequence of the deletion of the TRK1 gene encoding the sole potassium-specific transporter, has a pleiotropic effect. Here, we show that in addition to changes… read more here.
Keywords: potassium uptake; glabrata; surface properties; cell surface ... See more keywords
Cell wall composition and biofilm formation of azoles-susceptible and -resistant Candida glabrata strains
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DOI: 10.1080/1120009x.2016.1199507
Abstract: In the present study, three strains of Candida glabrata have been investigated to shed light on the mechanisms involved in azole resistance during adherence and biofilm formation. In particular, a clinical isolate, susceptible to azole-based… read more here.
Keywords: cell wall; biofilm formation; glabrata; wall composition ... See more keywords
Biguanides enhance antifungal activity against Candida glabrata
Sign Up to like & getrecommendations! Published in 2018 at "Virulence"
DOI: 10.1080/21505594.2018.1475798
Abstract: ABSTRACT Candida spp. are the fourth leading cause of nosocomial blood stream infections in North America. Candida glabrata is the second most frequently isolated species, and rapid development of antifungal resistance has made treatment a… read more here.
Keywords: biguanides enhance; glabrata; antifungal activity; activity ... See more keywords
A Review on Molecular Mechanisms of Antifungal Resistance in Candida glabrata: Update and Recent Advances.
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DOI: 10.1089/mdr.2020.0235
Abstract: Candida glabrata is the second frequent etiologic agent of mucosal and invasive candidiasis. Based on the recent developments in molecular methods, C. glabrata has been introduced as a complex composed of C. glabrata, Candida nivariensis,… read more here.
Keywords: glabrata; antifungal resistance; antifungal drugs; resistance ... See more keywords