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   Articles with "glabridin" as a keyword



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Enhanced skin permeation of glabridin using eutectic mixture-based nanoemulsion

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recommendations! Published in 2017 at "Drug Delivery and Translational Research"

DOI: 10.1007/s13346-017-0359-6

Abstract: This study aimed to investigate the performance of the eutectic mixture of menthol and camphor (1:1, w/w) in nanoemulsion formulation for enhanced transdermal penetration of water-insoluble glabridin. Glabridin solubility in different media was determined by… read more here.

Keywords: nanoemulsion; skin permeation; eutectic mixture; mixture ... See more keywords
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Anti-arthritic and cartilage damage prevention via regulation of Nrf2/HO-1 signaling by glabridin on osteoarthritis

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recommendations! Published in 2021 at "Arabian Journal of Chemistry"

DOI: 10.1016/j.arabjc.2021.103207

Abstract: Abstract Osteoarthritis is a common degenerative disease linked with inflammatory disorders and oxidative stress. Glabridin is an isoflavonoid and major active constituent of licorice. This study aims to investigate the anti-arthritic effects of glabridin on… read more here.

Keywords: prevention; glabridin; osteoarthritis; nrf2 signaling ... See more keywords
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Structural insights into the binding behavior of isoflavonoid glabridin with human serum albumin

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recommendations! Published in 2019 at "Food Hydrocolloids"

DOI: 10.1016/j.foodhyd.2019.01.031

Abstract: Abstract Glabridin (GB), a prenylated isoflavonoid in licorice root has been used as foods and medicines with beneficial biological activities. Human serum albumin (HSA) is the most abundant blood plasma protein binding and transporting ligands… read more here.

Keywords: hsa; glabridin; serum albumin; human serum ... See more keywords
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Glabridin inhibits osteoarthritis development by protecting chondrocytes against oxidative stress, apoptosis and promoting mTOR mediated autophagy.

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recommendations! Published in 2021 at "Life sciences"

DOI: 10.1016/j.lfs.2020.118992

Abstract: Osteoarthritis (OA) is a common chronic degenerative disease that affects the elderly. Thus far, no pharmacological therapy approved by regulators has shown a convincing effect on OA. Glabridin, a small molecule, is a well-known and… read more here.

Keywords: mediated autophagy; apoptosis; glabridin; mtor mediated ... See more keywords
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Glabridin ameliorates methotrexate-induced liver injury via attenuation of oxidative stress, inflammation, and apoptosis.

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recommendations! Published in 2021 at "Life sciences"

DOI: 10.1016/j.lfs.2021.119583

Abstract: Despite unprecedented advances in modern medicine, no safe and effective drug is available to date for oral administration to combat drug-induced liver injury, which is a vital concern nowadays. The present study deals with the… read more here.

Keywords: methotrexate induced; liver injury; induced liver; glabridin ... See more keywords
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Comprehensive Evaluation of Metabolism and the Contribution of the Hepatic First-Pass Effect in the Bioavailability of Glabridin in Rats.

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recommendations! Published in 2023 at "Journal of agricultural and food chemistry"

DOI: 10.1021/acs.jafc.2c06460

Abstract: Glabridin is a bioactive isoflavan, which has a wide range of biological properties and is widely used in the market of health products and dietary supplements. However, the transformation pathway of glabridin in vivo is… read more here.

Keywords: glabridin rats; pass effect; glabridin; bioavailability ... See more keywords
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Glabridin Plays Dual Action to Augment the Efficacy and Attenuate the Hepatotoxicity of Methotrexate in Arthritic Rats

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recommendations! Published in 2022 at "ACS Omega"

DOI: 10.1021/acsomega.2c03948

Abstract: Glabridin is chemically an isoflavane class of natural phenols and is found mainly in the roots of Glycyrrhiza glabra. It has several beneficial pharmacological actions for the management of inflammatory disorders as well as can… read more here.

Keywords: glabridin; mtx; methotrexate; hepatotoxicity ... See more keywords

Glabridin Inhibits Aspergillus fumigatus Growth and Alleviate Inflammation Mediated by Dectin-2 and NLRP3 Inflammasome

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recommendations! Published in 2023 at "Current Eye Research"

DOI: 10.1080/02713683.2022.2164779

Abstract: Abstract Purpose The research was used to uncover the mechanism of glabridin in Aspergillus fumigatus keratitis in anti-fungus and anti-inflammation. Methods In vitro, RAW 264.7 cells were infected with A. fumigatus with incubation of glabridin… read more here.

Keywords: fumigatus growth; glabridin; dectin nlrp3; dectin ... See more keywords
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Dehydrozingerone enhances the fungicidal activity of glabridin against Saccharomyces cerevisiae and Candida albicans.

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recommendations! Published in 2023 at "Letters in applied microbiology"

DOI: 10.1093/lambio/ovad040

Abstract: Drug resistance commonly occurs when treating immunocompromised patients with fungal infections. Dehydrozingerone-a phenolic compound isolated from the rhizome of Zingiber officinale-inhibits drug efflux in Saccharomyces cerevisiae by overexpression of the ATP-binding cassette (ABC) transporter Pdr5p.… read more here.

Keywords: glabridin; activity glabridin; dehydrozingerone enhances; activity ... See more keywords

Preparation of the Chitosan/Poly-γ-Glutamic Acid/Glabridin Hybrid Nanoparticles and Study on its Releasing Property.

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recommendations! Published in 2022 at "Current drug delivery"

DOI: 10.2174/1567201819666220513122319

Abstract: AIM The aim of this study was to encapsulate glabridin (GB) into nanoparticles which prepared by an ionic-gelation method blended with chitosan (CS) and poly-γ-glutamic acid (γ-PGA) to address the issue of poor stability and… read more here.

Keywords: pga; chitosan poly; glabridin; poly glutamic ... See more keywords
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Fungicidal Activity and Mechanism of Action of Glabridin from Glycyrrhiza glabra L.

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recommendations! Published in 2021 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms222010966

Abstract: Glycyrrhiza glabra (Licorice) belongs to the Fabaceae family and its extracts have exhibited significant fungicidal activity against phytopathogenic fungi, which has mainly been attributed to the presence of phenolic compounds such as flavonoids, isoflavonoids and… read more here.

Keywords: glycyrrhiza glabra; activity; fungicidal activity; glabridin ... See more keywords