Concomitant multiple sclerosis and polycythemia vera successfully treated with glatiramer acetate
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Hematology"
DOI: 10.1007/s00277-022-04839-2
Abstract: Polycythemia vera (PV) is a hematopoietic stem cell disorder characterized by janus kinase 2 (JAK2) mutations and an increased cardiovascular risk. Low-risk PV patients (those younger than 60 years of age and without thrombosis history)… read more here.
Keywords: treated glatiramer; successfully treated; risk; polycythemia vera ... See more keywords
Immunoregulation of Theiler’s virus-induced demyelinating disease by glatiramer acetate without suppression of antiviral immune responses
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Virology"
DOI: 10.1007/s00705-018-3729-6
Abstract: While most disease-modifying drugs (DMDs) regulate multiple sclerosis (MS) by suppressing inflammation, they can potentially suppress antiviral immunity, causing progressive multifocal leukoencephalopathy (PML). The DMD glatiramer acetate (GA) has been used for MS patients who… read more here.
Keywords: antiviral immune; immune responses; glatiramer acetate; disease ... See more keywords
Impact of Glatiramer Acetate on B Cell-Mediated Pathogenesis of Multiple Sclerosis
Sign Up to like & getrecommendations! Published in 2018 at "CNS Drugs"
DOI: 10.1007/s40263-018-0567-8
Abstract: Growing evidence indicates that B cells play a key role in the pathogenesis of multiple sclerosis (MS). B cells occupy distinct central nervous system (CNS) compartments in MS, including the cerebrospinal fluid and white matter… read more here.
Keywords: pathogenesis; multiple sclerosis; glatiramer acetate; pathogenesis multiple ... See more keywords
Induction of apoptosis in CD4(+) T-cells is linked with optimal treatment response in patients with relapsing-remitting multiple sclerosis treated with Glatiramer acetate
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Neurological Sciences"
DOI: 10.1016/j.jns.2019.03.030
Abstract: BACKGROUND Induction of T-cell apoptosis constitutes a mechanism of action for Glatiramer Acetate (GA). We investigated whether activation of apoptotic T-cell death may be indicative of optimal treatment response in patients with relapsing-remitting Multiple Sclerosis… read more here.
Keywords: treatment response; apoptosis; treatment; glatiramer acetate ... See more keywords
Induction of a higher-ordered architecture in glatiramer acetate improves its biological efficiency in an animal model of multiple sclerosis.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials science"
DOI: 10.1039/d0bm00957a
Abstract: Glatiramer acetate (GA), a linear random copolypeptide, is a first-line treatment for multiple sclerosis (MS). A major concern, however, is that GA treatment is associated with adverse effects and poor patient adherence due to the… read more here.
Keywords: treatment; higher ordered; ordered architecture; multiple sclerosis ... See more keywords
Development of Glatopa® (Glatiramer Acetate): The First FDA-Approved Generic Disease-Modifying Therapy for Relapsing Forms of Multiple Sclerosis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmacy Practice"
DOI: 10.1177/0897190017725984
Abstract: The multiple sclerosis (MS) treatment landscape in the United States has changed dramatically over the past decade. While many disease-modifying therapies (DMTs) have been approved by the US Food and Drug Administration (FDA) for the… read more here.
Keywords: glatopa; treatment; acetate; multiple sclerosis ... See more keywords
Immediate reactions with glatiramer acetate: Diagnosis of allergy and desensitization protocols.
Sign Up to like & getrecommendations! Published in 2020 at "Neurology: Clinical Practice"
DOI: 10.1212/cpj.0000000000000714
Abstract: Purpose of review Diverse adverse events have been associated with administration of glatiramer acetate (GA), mainly local reactions at the injection site. Other, less frequent generalized reactions include isolated postinjection reactions and anaphylaxis, which may… read more here.
Keywords: diagnosis; desensitization protocols; glatiramer acetate; allergy ... See more keywords
Management of immediate hypersensitivity reaction to glatiramer acetate
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Dermatology"
DOI: 10.1684/ejd.2016.2907
Abstract: Glatiramer acetate (GA; Copaxone®), a mixture of four synthetic polypeptides, is used in the form of subcutaneous injection (20 mg/day) for the treatment of multiple sclerosis (MS). Only few systemic reactions suggestive of anaphylaxis have… read more here.
Keywords: management immediate; glatiramer acetate; reaction; immediate hypersensitivity ... See more keywords
Treatment Challenges in Multiple Sclerosis – A Continued Role for Glatiramer Acetate?
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.844873
Abstract: Earlier diagnosis, access to disease-modifying therapies (DMTs), and improved supportive care have favorably altered the disease course of multiple sclerosis (MS), leading to an improvement in long-term outcomes for people with MS (PwMS). This success… read more here.
Keywords: treatment challenges; glatiramer acetate; challenges multiple; treatment ... See more keywords
Differential Transcription of SOCS5 and SOCS7 in Multiple Sclerosis Patients Treated with Interferon Beta or Glatiramer Acetate
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21010218
Abstract: The participation of proinflammatory cytokines in the progression of Multiple Sclerosis (MS) has been well documented. Cytokines activate the JAK-STAT pathway, in which the suppressors of cytokine signaling (SOCS) exert a negative feedback. This paper… read more here.
Keywords: socs5 socs7; multiple sclerosis; glatiramer acetate; patients treated ... See more keywords
Evaluation of the Antiviral Activity of Sitagliptin-Glatiramer Acetate Nano-Conjugates against SARS-CoV-2 Virus
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceuticals"
DOI: 10.3390/ph14030178
Abstract: The outbreak of the COVID-19 pandemic in China has become an urgent health and economic challenge. There is a current race for developing strategies to treat and/or prevent COVID-19 worldwide. Severe acute respiratory syndrome coronavirus… read more here.
Keywords: nano conjugates; sit; glatiramer acetate; cov virus ... See more keywords